Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776032 | 0.95 | KCNH2 (0.41) | KCNH2CYP2C9ALOX5APRPS6KA2FGFR4 | |
| SCHEMBL16776177 | 0.91 | RPS6KA2 (0.40) | KCNH2CYP2C9ALOX5APRPS6KA2FGFR4 | |
| SCHEMBL16776143 | 0.90 | RPS6KA2 (0.39) | KCNH2CYP2C9ALOX5APRPS6KA2FGFR4 | |
| SCHEMBL16776239 | 0.86 | ABL1 (0.40) | KCNH2CYP2C9ALOX5APRPS6KA2FGFR4 | |
| SCHEMBL16776028 | 0.86 | FGFR4 (0.38) | KCNH2CYP2C9ALOX5APRPS6KA2FGFR4 | |
| SCHEMBL16776037 | 0.85 | FGFR4 (0.37) | KCNH2CYP2C9ALOX5APRPS6KA2FGFR4 | |
| SCHEMBL16776045 | 0.85 | RPS6KA2 (0.38) | KCNH2CYP2C9ALOX5APRPS6KA2FGFR4 | |
| SCHEMBL16776127 | 0.85 | RPS6KA2 (0.38) | KCNH2CYP2C9ALOX5APRPS6KA2FGFR4 | |
| SCHEMBL16776258 | 0.84 | CYP2C9 (0.38) | KCNH2CYP2C9ALOX5APRPS6KA2FGFR4 | |
| SCHEMBL16776198 | 0.84 | GRM5 (0.39) | KCNH2ABL1HRH3POLBGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | KCNH2 4052/4885CYP2C9 2535/4885ALOX5AP 3669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.