Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31218819 | 0.73 | TYK2 (0.46) | TYK2PDE4D | |
| SCHEMBL31218754 | 0.67 | TYK2 (0.49) | TYK2PDE4D | |
| SCHEMBL20697100 | 0.63 | TYK2 (1.00) | TYK2 | |
| SCHEMBL20678916 | 0.59 | TYK2 (1.00) | TYK2 | |
| SCHEMBL18692248 | 0.59 | CFTR (0.55) | CFTR | |
| SCHEMBL31218703 | 0.58 | TYK2 (0.70) | TYK2PDE4D | |
| SCHEMBL24263296 | 0.58 | TYK2 (0.78) | TYK2PDE4D | |
| SCHEMBL29754460 | 0.58 | TYK2 (0.78) | TYK2PDE4D | |
| SCHEMBL18717671 | 0.58 | CFTR (0.64) | CFTR | |
| SCHEMBL5189021 | 0.58 | RIPK2 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080131-A1 | IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | Bristol-Myers Squibb Company (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015089143-A1 | IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-06-18 | — | — | WO | disclosed |