Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | RHEB | Q15382 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16804211 | 0.85 | MAPK10 (0.46) | HDAC6HDAC1HDAC4ALDH1A1MAPK10 | |
| SCHEMBL15712169 | 0.83 | NOTUM (0.47) | NOTUML3MBTL1HSD17B10 | |
| SCHEMBL20437193 | 0.81 | TP53 (0.42) | MEN1KMT2ATP53HDAC6HDAC1 | |
| SCHEMBL2887633 | 0.80 | SCN9A (0.42) | HDAC6HDAC1HDAC4ALDH1A1MAPK10 | |
| SCHEMBL29663821 | 0.77 | ABL1 (0.48) | MEN1KMT2ATP53HDAC6HDAC1 | |
| SCHEMBL660025 | 0.77 | ABL1 (0.48) | MEN1KMT2ATP53HDAC6HDAC1 | |
| SCHEMBL16794749 | 0.77 | HTR6 (0.51) | MEN1KMT2ATP53PABPC1 | |
| SCHEMBL16794756 | 0.77 | MEN1 (0.46) | MEN1KMT2ATP53PABPC1RHEB | |
| SCHEMBL16794793 | 0.76 | MEN1 (0.43) | MEN1KMT2ATP53PABPC1RHEB | |
| Hydrochloric Acid SCHEMBL16794755 | 0.76 | HTR6 (0.50) | MEN1KMT2ATP53PABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080125-A1 | NOVEL AZAINDOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE (HDAC) INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | Chong Kun Dang Pharmaceutical Corp. (KR) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015087151-A1 | NOVEL AZAINDOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE (HDAC) INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2015-06-18 | — | — | WO | disclosed |