Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 5/20 | 0.41 |
| ▸ | CA2 | P00918 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3416554 | 0.88 | PRMT5 (0.58) | HIF1APRMT5WDR77CA1CA2 | |
| SCHEMBL16321506 | 0.87 | TSHR (0.46) | HIF1APRMT5WDR77CA1CA2 | |
| SCHEMBL18989327 | 0.87 | PRMT5 (0.47) | HIF1APRMT5WDR77CA1CA2 | |
| SCHEMBL12502664 | 0.87 | HIF1A (0.48) | HIF1APRMT5WDR77CA1CA2 | |
| SCHEMBL28616950 | 0.84 | ROCK1 (0.52) | HIF1APRMT5WDR77CA1CA2 | |
| SCHEMBL21682668 | 0.79 | HIF1A (0.50) | HIF1ACA1CA2CA9CA12 | |
| SCHEMBL16795375 | 0.79 | HIF1A (0.46) | HIF1APRMT5WDR77CA1CA2 | |
| SCHEMBL23732881 | 0.78 | LIPG (0.51) | HIF1APRMT5WDR77CA1CA2 | |
| SCHEMBL3413800 | 0.77 | PRMT5 (0.57) | HIF1APRMT5WDR77CA1CA2 | |
| SCHEMBL3416221 | 0.76 | PRMT5 (0.56) | HIF1APRMT5WDR77CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015086693-A1 | PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2015-06-18 | — | — | WO | disclosed |