Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.48 |
| ▸ | JAK1 | P23458 | 11/20 | 0.48 |
| ▸ | JAK3 | P52333 | 11/20 | 0.48 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CCNK | O75909 | 2/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CCNH | P51946 | 2/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.46 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16795450 | 1.00 | JAK2 (0.48) | JAK2JAK1JAK3CDK2CCNT1 | |
| SCHEMBL16795293 | 0.86 | CCNT1 (0.61) | JAK2JAK1JAK3CDK2CCNT1 | |
| SCHEMBL18302195 | 0.84 | JAK2 (0.68) | JAK2JAK1JAK3IRAK4 | |
| SCHEMBL18302190 | 0.80 | JAK2 (0.64) | JAK2JAK1JAK3 | |
| SCHEMBL16795182 | 0.80 | JAK2 (0.64) | JAK2JAK1JAK3 | |
| SCHEMBL16795132 | 0.78 | JAK2 (0.40) | JAK2JAK1JAK3 | |
| SCHEMBL16795190 | 0.77 | JAK2 (0.66) | JAK2JAK1JAK3 | |
| SCHEMBL16795188 | 0.77 | JAK2 (0.66) | JAK2JAK1JAK3 | |
| SCHEMBL18302099 | 0.76 | JAK2 (0.66) | JAK2JAK1JAK3CDK2CCNT1 | |
| SCHEMBL18302167 | 0.75 | CCNT1 (0.57) | JAK2JAK1JAK3CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015086693-A1 | PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2015-06-18 | — | — | WO | disclosed |