Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CPN1 | P15169 | 2/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 4/20 | 0.35 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.35 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.35 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19532417 | 0.87 | CPN1 (0.42) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL1802274 | 0.87 | CPN1 (0.42) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL22776079 | 0.81 | CPN1 (0.46) | CPN1CPB2SLC6A1SLC6A11SLC6A13 | |
| SCHEMBL9289911 | 0.81 | CPN1 (0.37) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL4592868 | 0.81 | KDM4E (0.41) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL13713582 | 0.79 | SLC6A1 (0.39) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL29496835 | 0.78 | KDM4E (0.38) | KDM4EMAPTKMT2AATMCYP2D6 | |
| Hydrochloric Acid SCHEMBL17560474 | 0.76 | KDM4E (0.37) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL6913823 | 0.76 | CPN1 (0.34) | CPN1CPB2SLC6A1SLC6A11SLC6A13 | |
| Hydrochloric Acid SCHEMBL30948839 | 0.76 | KDM4E (0.37) | KDM4EMAPTKMT2AATMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080602-A2 | TREATING NEURODEGENERATIVE DISEASE | The Brigham and Women's Hospital, Inc. (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015089443-A2 | TREATING NEURODEGENERATIVE DISEASE | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2015-06-18 | — | — | WO | disclosed |