Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | BMP1 | P13497 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16796532 | 1.00 | KCNH2 (0.44) | KCNH2ADRB3BMP1MMP1MMP2 | |
| SCHEMBL16796534 | 0.86 | KCNH2 (0.50) | KCNH2ADRB3NR1D1 | |
| SCHEMBL1993401 | 0.83 | KCNH2 (0.47) | KCNH2ADRB3NR1D1 | |
| SCHEMBL19491464 | 0.82 | KCNH2 (0.52) | KCNH2BMP1MMP1MMP2MMP9 | |
| SCHEMBL17177098 | 0.80 | KCNH2 (0.45) | KCNH2 | |
| SCHEMBL16682344 | 0.80 | KCNH2 (0.53) | KCNH2MMP1MMP2MMP9MMP8 | |
| SCHEMBL19491362 | 0.79 | KCNH2 (0.52) | KCNH2BMP1NR1D1 | |
| SCHEMBL16796531 | 0.78 | GAA (0.36) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL16796533 | 0.78 | GAA (0.36) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL16796543 | 0.78 | GAA (0.36) | MMP1MMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10337039-B2 | Process for the preparation of chiral 2-aryl morpholines | HOFFMANN-LA ROCHE INC. (US) | 2019-07-02 | — | — | US | disclosed |
| EP-3080284-B1 | PROCESS FOR THE PREPARATION OF A CHIRAL 2-(4-AMINOPHENYL)MORPHOLINE | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | disclosed |
| EP-3080284-A1 | PROCESS FOR THE PREPARATION OF CHIRAL 2-ARYL MORPHOLINES | F. Hoffmann-La Roche AG (CH) | 2016-10-19 | — | — | EP | disclosed |
| US-20160289718-A1 | PROCESS FOR THE PREPARATION OF CHIRAL 2-ARYL MORPHOLINES | HOFFMANN-LA ROCHE INC. (US) | 2016-10-06 | — | — | US | disclosed |
| WO-2015086495-A1 | PROCESS FOR THE PREPARATION OF CHIRAL 2-ARYL MORPHOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10337039-B2 | Process for the preparation of chiral 2-aryl morpholines | TAAR1, TAAR5, TACR2 | KCNH2 745/4885ADRB3 75/4885BMP1 931/4885 |
| US-20160289718-A1 | PROCESS FOR THE PREPARATION OF CHIRAL 2-ARYL MORPHOLINES | TAAR1, TAAR5, TACR2 | KCNH2 745/4885ADRB3 75/4885BMP1 931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.