TAAR5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL359453	1.00	1/20
SCHEMBL29374539	1.00	1/20
SCHEMBL13886676	0.79	1/20
SCHEMBL13886597	0.74	1/20
SCHEMBL13886593	0.74	1/20
SCHEMBL25772997	0.74	1/20
SCHEMBL13886618	0.73	1/20
Hydrochloric Acid (SCHEMBL5311045)	0.72	1/20
Hydrochloric Acid (SCHEMBL5317226)	0.71	1/20
SCHEMBL13886678	0.69	1/20
SCHEMBL13886598	0.68	1/20
SCHEMBL13886734	0.68	1/20
SCHEMBL14230065	0.68	1/20
SCHEMBL23996877	0.68	1/20
SCHEMBL14230100	0.66	1/20
SCHEMBL27293661	0.66	1/20
SCHEMBL13894715	0.65	1/20
SCHEMBL28572686	0.65	1/20
SCHEMBL25773004	0.64	1/20
SCHEMBL17141553	0.63	1/20

Clinical trials — most relevant to TAAR5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Genotype on Resting State Connectivity During Methamphetamine Administration	PHASE4	COMPLETED
Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI	PHASE4	RECRUITING
Medication, Weight Gain and GI Hormones	PHASE4	COMPLETED
Placebo-Controlled Cross Over Trial of Chlorzoxazone Intake	PHASE4	COMPLETED
Safety and Efficacy Study of Topiramate to Aid in Smoking Cessation	PHASE3	COMPLETED
Psychopharmacology for Cocaine Dependence - Buspirone	PHASE2	COMPLETED
Varenicline (Chantix™) for the Treatment of Alcohol Dependence	PHASE2	COMPLETED
Safety and Efficacy of MEM 3454 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
The Effect of Ginger on the Incidence of Postoperative Nausea and Vomiting	PHASE2	COMPLETED
A Study of Quetiapine and Mirtazapine for the Treatment of Alcohol Dependency	PHASE2	COMPLETED
Diclofenac Dose Response Study	PHASE1	RECRUITING
RTI-336 as a Treatment for Methamphetamine Dependence	PHASE1	WITHDRAWN
Neuronal Correlates of Altered States of Consciousness	EARLY_PHASE1	COMPLETED
Caffeine Efficacy in ADCY5-related Dyskinesia	nan	UNKNOWN
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Serotonin Transporters in Alcoholism	nan	COMPLETED
Investigation of the Neurovegetative Pattern in Patients With Thoracic Aortic Aneurysms (TAA)	nan	ACTIVE_NOT_RECRUITING
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Common Noradrenergic Mechanisms in Parkinson´s Disease and L-DOPA Induced Dyskinesia	nan	UNKNOWN
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling	nan	UNKNOWN
Brain Tissue Integrity and Autonomic Function Alterations in Childhood OSA and ADHD, and After Adenotonsillectomy.	nan	UNKNOWN
Preemptive Oral Gabapentin and Tramadol on Postoperative Pain After Knee Arthroscopy	nan	COMPLETED
Affective Touch, Hedonia and Suicidal Behavior	nan	COMPLETED
Examination of Brain Serotonin Receptors in Patients With Mood Disorders	nan	COMPLETED
The Genetic Basis for Vulnerability to Substance Abuse	nan	COMPLETED
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling	nan	COMPLETED
Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging	nan	COMPLETED
Effects of Prazosin on the Attention-Enhancing Effects of Nicotine	nan	WITHDRAWN

Related proteins — ESM-2 sequence neighbours (a TAAR5 binder may also engage these)

Protein	Name	Similarity
Q5QD28	—	1.000	Q5QD28 →
Q5QD23	—	1.000	Q5QD23 →
Q5QD14	—	0.998	Q5QD14 →
Q923Y9	—	0.991	Q923Y9 →
Q923Y7	—	0.991	Q923Y7 →
Q5QNP2	—	0.990	Q5QNP2 →
Q5QD15	—	0.988	Q5QD15 →
Q5QD16	—	0.988	Q5QD16 →
Q923Y8	—	0.987	Q923Y8 →
Q923X6	—	0.987	Q923X6 →
Q5QD17	—	0.984	Q5QD17 →
Q5QD08	—	0.984	Q5QD08 →
Q923X5	—	0.983	Q923X5 →
Q5QD25	—	0.983	Q5QD25 →
Q9P1P5	—	0.982	Q9P1P5 →
Q5QD24	—	0.981	Q5QD24 →
TAAR1	Trace amine-associated receptor 1	0.980	landscape →
Q923Y1	—	0.980	Q923Y1 →
Q5QD12	—	0.980	Q5QD12 →
Q5QD29	—	0.979	Q5QD29 →
Q5QD10	—	0.978	Q5QD10 →
Q5QD09	—	0.977	Q5QD09 →
Q923Y4	—	0.976	Q923Y4 →
Q923X9	—	0.976	Q923X9 →
Q9P1P4	—	0.976	Q9P1P4 →
Q923X8	—	0.976	Q923X8 →
Q8HZ64	—	0.975	Q8HZ64 →
Q923Y2	—	0.974	Q923Y2 →
Q5QD21	—	0.974	Q5QD21 →
Q923Y5	—	0.974	Q923Y5 →