Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16796611 | 0.88 | P2RX4 (0.39) | P2RX4CHRM4DRD2HTR7ALDH1A1 | |
| SCHEMBL16796715 | 0.86 | P2RX4 (0.42) | P2RX4CHRM4DRD2HTR7ALDH1A1 | |
| SCHEMBL16796602 | 0.86 | P2RX4 (0.43) | P2RX4CHRM4DRD2HTR7ALDH1A1 | |
| SCHEMBL16796578 | 0.86 | P2RX4 (0.43) | P2RX4CHRM4DRD2HTR7ALDH1A1 | |
| SCHEMBL16812979 | 0.84 | CHRM4 (0.59) | P2RX4CHRM4DRD2HTR7ALDH1A1 | |
| SCHEMBL16812981 | 0.83 | CHRM4 (0.46) | P2RX4CHRM4DRD2HTR7ALDH1A1 | |
| SCHEMBL16813008 | 0.82 | P2RX4 (0.46) | P2RX4CHRM4DRD2HTR7ALDH1A1 | |
| SCHEMBL16813006 | 0.82 | P2RX4 (0.46) | P2RX4CHRM4DRD2HTR7ALDH1A1 | |
| SCHEMBL16796638 | 0.82 | P2RX4 (0.39) | P2RX4CHRM4DRD2HTR7KMT2A | |
| SCHEMBL16796688 | 0.81 | P2RX4 (0.47) | P2RX4CHRM4DRD2HTR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015088565-A1 | P2X4 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| WO-2015088565-A1 | P2X4 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2015-06-18 | — | — | WO | disclosed |