Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.61 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 6/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | GRK5 | P34947 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1679768 | 0.88 | PRKD3 (0.67) | PRKD3PRKD1PRKD2FYNMAP4K4 | |
| SCHEMBL1679470 | 0.86 | PRKD3 (0.65) | PRKD3PRKD1PRKD2FYNMAP4K4 | |
| SCHEMBL1679776 | 0.85 | PRKD3 (0.63) | PRKD3PRKD1PRKD2FYNMAP4K4 | |
| SCHEMBL14189748 | 0.85 | TGFBR1 (0.50) | FYNMAP4K4GRK5PDE4BMMP1 | |
| SCHEMBL1679176 | 0.84 | PRKD3 (0.71) | PRKD3PRKD1PRKD2FYNMAP4K4 | |
| SCHEMBL1679192 | 0.83 | PRKD3 (0.70) | PRKD3PRKD1PRKD2FYNMAP4K4 | |
| SCHEMBL2387166 | 0.83 | PRKD3 (0.60) | PRKD3PRKD1PRKD2FYNMAP4K4 | |
| SCHEMBL1679194 | 0.82 | PRKD3 (0.64) | PRKD3PRKD1PRKD2FYNMAP4K4 | |
| SCHEMBL14189985 | 0.82 | PRKD3 (0.74) | PRKD3PRKD1PRKD2FYNMAP4K4 | |
| SCHEMBL1679743 | 0.82 | PRKD3 (0.74) | PRKD3PRKD1PRKD2FYNMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098325-A1 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-04-28 | — | — | US | claimed |
| US-20110098325-A1 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-04-28 | — | — | US | disclosed |
| US-20110098325-A1 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-04-28 | — | — | US | disclosed |
| US-20110098325-A1 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-04-28 | — | — | US | disclosed |
| WO-2008074997-A1 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098325-A1 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS | PKD2, PKD1, BAZ2B | PRKD3 38/4885PRKD1 33/4885PRKD2 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.