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Arginine

Arginine

SCHEMBL16797281

CC(C)C[C@H](N)C(=O)O.CC(C)C[C@H](N)C(=O)OC(=O)[C@@H](N)Cc1ccccc1.CC(C)[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)OC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 9/20 0.36
▸ NPY1R P25929 6/20 0.36
▸ FNTA P49354 3/20 0.36
▸ FNTB P49356 3/20 0.36
▸ PGGT1B P53609 3/20 0.36
▸ NPY2R P49146 4/20 0.35
▸ NPY5R Q15761 4/20 0.35
▸ ANPEP P15144 2/20 0.33
▸ RNPEP Q9H4A4 2/20 0.33
▸ DNPEP Q9ULA0 2/20 0.33
▸ TACR3 P29371 1/20 0.33
▸ KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arginine SCHEMBL16797368 0.88 NPY4R (0.40) NPY4RNPY1RNPY2RNPY5RANPEP
Arginine SCHEMBL5951212 0.87 NPY4R (0.45) NPY4RNPY1RNPY2RNPY5RANPEP
Arginine SCHEMBL2197566 0.85 TFPI (0.36) —
Arginine SCHEMBL5342137 0.84 NPY4R (0.47) NPY4RNPY1RNPY2RNPY5RANPEP
Arginine SCHEMBL27486583 0.80 NPY4R (0.44) NPY4RNPY1RFNTAFNTBPGGT1B
Arginine SCHEMBL28458140 0.79 FNTA (0.42) FNTAFNTBPGGT1BANPEPRNPEP
Phenylalanine SCHEMBL4612880 0.78 ALPI (0.38) FNTAFNTBPGGT1BANPEPRNPEP
Arginine SCHEMBL27672191 0.78 ANPEP (0.45) NPY4RNPY1RNPY2RNPY5RANPEP
Arginine SCHEMBL28620239 0.78 NPY4R (0.42) NPY4RNPY1RFNTAFNTBPGGT1B
Arginine SCHEMBL6046858 0.78 FNTA (0.49) NPY4RNPY1RFNTAFNTBPGGT1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10286050-B2 Multi-epitope TARP peptide vaccine and uses thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2019-05-14 — — US disclosed
EP-3079716-B1 MULTI-EPITOPE TARP PEPTIDE VACCINE AND USES THEREOF US HEALTH (US) 2019-05-08 — — EP disclosed
US-20160310585-A1 MULTI-EPITOPE TARP PEPTIDE VACCINE AND USES THEREOF THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2016-10-27 — — US disclosed
EP-3079716-A1 MULTI-EPITOPE TARP PEPTIDE VACCINE AND USES THEREOF The United States Of America, As Represented By The Secretary, Department Of Health And Human Services (US) 2016-10-19 — — EP disclosed
WO-2015089469-A1 MULTI-EPITOPE TARP PEPTIDE VACCINE AND USES THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2015-06-18 — — WO disclosed