Sugi Predict

Sugi Predict / Compounds / SCHEMBL16799485

SCHEMBL16799485

SCHEMBL16799485

O=C1C[C@@H](c2cccc(C(F)(F)F)c2)CN1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ HTR2C P28335 3/20 0.55
▸ PDE4A P27815 7/20 0.48
▸ PDE4B Q07343 3/20 0.48
▸ PDE4C Q08493 3/20 0.48
▸ PDE4D Q08499 3/20 0.48
▸ ALDH1A1 P00352 1/20 0.48
▸ CYP1A2 P05177 1/20 0.48
▸ CYP2C19 P33261 1/20 0.48
▸ HTR1A P08908 1/20 0.46
▸ HTR2A P28223 1/20 0.45
▸ HTR2B P41595 1/20 0.45
▸ DRD2 P14416 1/20 0.44
▸ MTNR1A P48039 1/20 0.43
▸ PBRM1 Q86U86 1/20 0.42
▸ TTR P02766 1/20 0.42
▸ PIM1 P11309 1/20 0.42
▸ CISD1 Q9NZ45 1/20 0.42
▸ PIM2 Q9P1W9 1/20 0.42
▸ GRM2 Q14416 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1269261 1.00 HTR2C (0.55) HTR2CPDE4APDE4BPDE4CPDE4D
SCHEMBL1410448 0.84 PDE4A (0.45) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL8352445 0.81 TSHR (0.53) HTR2CPDE4APDE4BPDE4CPDE4D
SCHEMBL1268440 0.80 PDE4A (0.51) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL427827 0.79 HTR2C (0.58) HTR2CHTR1AHTR2AHTR2BDRD2
SCHEMBL24007592 0.78 PDE4A (0.40) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL18051413 0.78 PDE4A (0.43) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL17729642 0.77 HTR2C (0.70) HTR2CHTR1AHTR2AHTR2BDRD2
SCHEMBL11101873 0.76 PDE4A (0.51) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL20475360 0.76 PDE4A (0.51) PDE4APDE4BPDE4CPDE4DALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4086240-B1 PYRROLIDINONE HERBICIDES FMC CORP (US) 2025-02-05 — — EP disclosed
US-12077503-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2024-09-03 — — US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 — — US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 — — US disclosed
US-20230270111-A1 PYRROLIDINONES HERBICIDES E.I. DU PONT DE NEMOURS AND COMPANY 2023-08-31 — — US disclosed
US-11589583-B2 Pyrrolidinones herbicides FMC CORPORATION (US) 2023-02-28 — — US disclosed
US-11528906-B2 Pyrrolidinones as herbicides FMC CORPORATION (US) 2022-12-20 — — US disclosed
EP-4086240-A1 PYRROLIDINONE HERBICIDES FMC Corporation (US) 2022-11-09 — — EP disclosed
EP-3663282-B1 PYRROLIDINONE HERBICIDES FMC CORP (US) 2022-05-18 — — EP disclosed
US-20220132844-A1 PYRROLIDINONES AS HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY 2022-05-05 — — US disclosed
CN-106414403-B Pyrrolidinone herbicides FMC公司 2019-08-30 — — CN disclosed
US-10294202-B2 Pyrrolidinones as herbicides FMC CORPORATION (US) 2019-05-21 — — US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 — — US disclosed
EP-3303321-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES E. I. du Pont de Nemours and Company (US) 2018-04-11 — — EP disclosed
CN-107709310-A Substituted cyclic amides and its purposes as herbicide 杜邦公司 2018-02-16 — — CN disclosed
CN-106414403-A Pyrrolidinone herbicides 纳幕尔杜邦公司 2017-02-15 — — CN disclosed
WO-2016196593-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES E I DU PONT DE NEMOURS AND COMPANY (US) 2016-12-08 — — WO disclosed
US-20160297756-A1 PYRROLIDINONES AS HERBICIDES FMC CORPORATION 2016-10-13 — — US disclosed
EP-3077374-A1 PYRROLIDINONES AS HERBICIDES E. I. du Pont de Nemours and Company (US) 2016-10-12 — — EP disclosed
WO-2015084796-A1 PYRROLIDINONES AS HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2015-06-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11589583-B2 Pyrrolidinones herbicides DDT, ARG1, CYP1B1 HTR2C 2103/4885PDE4A 752/4885PDE4B 882/4885
US-20220132844-A1 PYRROLIDINONES AS HERBICIDES DDT, ARG1, PRMT1 HTR2C 2373/4885PDE4A 764/4885PDE4B 870/4885
US-20160297756-A1 PYRROLIDINONES AS HERBICIDES DDT, ARG1, PRMT1 HTR2C 2373/4885PDE4A 764/4885PDE4B 870/4885
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 HTR2C 3066/4885PDE4A 1013/4885PDE4B 1039/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 HTR2C 3066/4885PDE4A 1013/4885PDE4B 1039/4885
US-10294202-B2 Pyrrolidinones as herbicides DDT, ARG1, PRMT1 HTR2C 2373/4885PDE4A 764/4885PDE4B 870/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 HTR2C 3088/4885PDE4A 986/4885PDE4B 1008/4885
US-20230270111-A1 PYRROLIDINONES HERBICIDES DDT, ARG1, CYP1B1 HTR2C 2103/4885PDE4A 752/4885PDE4B 882/4885
US-12077503-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 HTR2C 3088/4885PDE4A 986/4885PDE4B 1008/4885
US-11528906-B2 Pyrrolidinones as herbicides DDT, ARG1, PRMT1 HTR2C 2373/4885PDE4A 764/4885PDE4B 870/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.