Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | NT5E | P21589 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18148263 | 0.86 | NAMPT (0.73) | NAMPTMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL18148261 | 0.76 | MAPK10 (0.55) | NAMPTMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL16802693 | 0.74 | MAPK10 (0.67) | NAMPTMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL25135598 | 0.70 | NT5E (0.59) | MAPK13NT5EJAK2TYK2MEN1 | |
| SCHEMBL3703284 | 0.69 | NAMPT (1.00) | NAMPTKDREGFRFGFR1 | |
| SCHEMBL3646841 | 0.67 | NT5E (0.68) | NT5EJAK2TYK2MEN1PKM | |
| SCHEMBL2129797 | 0.67 | EGFR (0.64) | NAMPTMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL27113204 | 0.67 | ALDH1A1 (0.65) | MEN1PKMKMT2AL3MBTL1 | |
| SCHEMBL15248154 | 0.67 | KDR (0.83) | KDRPDGFRB | |
| SCHEMBL181948 | 0.66 | MEN1 (0.65) | MAPK14MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3076789-A1 | NOVEL COMPOUNDS AS JNK KINASE INHIBITORS | The Scripps Research Institute (US) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015084936-A1 | NOVEL COMPOUNDS AS JNK KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-06-11 | — | — | WO | disclosed |