Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 12/20 | 0.56 |
| ▸ | MLYCD | O95822 | 2/20 | 0.52 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.50 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RORA | P35398 | 4/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18151717 | 0.80 | RORC (0.77) | RORCMLYCDRORA | |
| SCHEMBL18151833 | 0.79 | RORC (0.61) | RORCMLYCDRORANR1H2NR1H3 | |
| SCHEMBL16799918 | 0.73 | MAPT (0.44) | RORCKCNJ5KCNJ3SMN1; SMN2GAA | |
| SCHEMBL6922110 | 0.73 | RORC (0.64) | RORCMLYCDSMN1; SMN2RORANR1H2 | |
| SCHEMBL17114558 | 0.72 | RORC (0.80) | RORCMLYCDSMN1; SMN2RORA | |
| SCHEMBL16799660 | 0.72 | RORC (0.43) | RORCKCNJ5KCNJ3SMN1; SMN2GAA | |
| SCHEMBL17114492 | 0.71 | RORC (1.00) | RORCRORA | |
| SCHEMBL17114529 | 0.71 | RORC (0.74) | RORCMLYCDSMN1; SMN2RORA | |
| SCHEMBL18151719 | 0.71 | RORC (0.77) | RORCRORA | |
| SCHEMBL11463482 | 0.71 | SMN1; SMN2 (0.71) | RORCMLYCDSMN1; SMN2RORA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077372-A1 | ROR GAMMA (RORY) MODULATORS | Lead Pharma Cel Models IP B.V. (NL) | 2016-10-12 | — | — | EP | claimed |
| WO-2015082533-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2015-06-11 | — | — | WO | claimed |