Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.60 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16800568 | 0.88 | MAP2K1 (0.64) | KDRMAP2K1MAPK14EGFRERBB2 | |
| SCHEMBL16800731 | 0.83 | EGFR (0.52) | KDREGFRERBB2AURKARPS6KB1 | |
| SCHEMBL5739243 | 0.82 | KDR (0.60) | KDRMAP2K1MAPK14EGFRERBB2 | |
| SCHEMBL4042333 | 0.80 | KDR (0.75) | KDRMAP2K1MAPK14EGFRERBB2 | |
| SCHEMBL28749813 | 0.80 | KDR (0.58) | KDRMAP2K1MAPK14EGFRERBB2 | |
| SCHEMBL16800829 | 0.80 | KDR (0.49) | KDRMAPK14EGFRERBB2AURKA | |
| SCHEMBL12728722 | 0.79 | KDR (0.62) | KDRCSNK2A2CSNK2BCSNK2A1MAP2K1 | |
| SCHEMBL5516114 | 0.79 | KDR (0.80) | KDREGFR | |
| SCHEMBL7530745 | 0.78 | KDR (0.70) | KDRMAP2K1MAPK14EGFRERBB2 | |
| SCHEMBL4053778 | 0.78 | KDR (0.78) | KDRMAP2K1MAPK14EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015081783-A1 | PYRROLO[2,1-F][1,2,4]TRIAZINE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF | 江苏奥赛康药业股份有限公司 | 2015-06-11 | — | — | WO | disclosed |