Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051959 | 0.90 | KDR (0.75) | KDRMAP2K1EGFRERBB2MAPK14 | |
| SCHEMBL7583147 | 0.86 | MAPK14 (0.58) | KDREGFRMAPK14 | |
| SCHEMBL5740244 | 0.82 | KDR (0.54) | KDRMAP2K1EGFRERBB2MAPK14 | |
| SCHEMBL28749813 | 0.82 | KDR (0.58) | KDRMAP2K1EGFRERBB2MAPK14 | |
| SCHEMBL16800730 | 0.82 | KDR (0.60) | KDRMAP2K1EGFRERBB2MAPK14 | |
| SCHEMBL12728722 | 0.79 | KDR (0.62) | KDRMAP2K1EGFRMAPK14 | |
| SCHEMBL5516114 | 0.79 | KDR (0.80) | KDREGFR | |
| SCHEMBL7530745 | 0.78 | KDR (0.70) | KDRMAP2K1EGFRERBB2MAPK14 | |
| SCHEMBL4053778 | 0.78 | KDR (0.78) | KDRMAP2K1EGFRERBB2MAPK14 | |
| SCHEMBL4044821 | 0.77 | MAPK14 (0.69) | KDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |