Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.66 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16764181 | 0.88 | BTK (0.71) | BTKJAK3LCKEGFR | |
| SCHEMBL16764183 | 0.88 | BTK (0.71) | BTKJAK3LCKEGFR | |
| SCHEMBL28096707 | 0.85 | BTK (0.79) | BTKJAK3LCKEGFR | |
| SCHEMBL28096702 | 0.85 | BTK (0.79) | BTKJAK3LCKEGFR | |
| SCHEMBL16801928 | 0.84 | BTK (0.50) | BTKJAK3ATRJAK2TYK2 | |
| SCHEMBL16763644 | 0.81 | BTK (1.00) | BTKJAK3LCKEGFR | |
| SCHEMBL16764178 | 0.81 | BTK (0.79) | BTKJAK3LCKEGFR | |
| SCHEMBL16764176 | 0.81 | BTK (0.79) | BTKJAK3LCKEGFR | |
| SCHEMBL16763641 | 0.81 | BTK (1.00) | BTKJAK3LCKEGFR | |
| SCHEMBL23080983 | 0.80 | LCK (0.54) | BTKJAK3LCKCSF1RSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015084998-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2015-06-11 | — | — | WO | disclosed |