Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | TSHR | P16473 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9281762 | 0.90 | ALDH1A1 (0.41) | ALDH1A1TSHRLMNAKMT2AL3MBTL1 | |
| SCHEMBL2708771 | 0.87 | KMT2A (0.43) | ALDH1A1TSHRLMNAKMT2AL3MBTL1 | |
| SCHEMBL9213899 | 0.87 | KMT2A (0.43) | ALDH1A1TSHRLMNAKMT2AL3MBTL1 | |
| SCHEMBL690316 | 0.84 | ALDH1A1 (0.39) | ALDH1A1TSHRLMNAKMT2AL3MBTL1 | |
| SCHEMBL12661134 | 0.83 | CHEK2 (0.38) | ALDH1A1TSHRLMNAKMT2AL3MBTL1 | |
| SCHEMBL12965902 | 0.82 | USP30 (0.41) | ALDH1A1TSHRLMNAKMT2AL3MBTL1 | |
| SCHEMBL12938495 | 0.82 | USP30 (0.41) | ALDH1A1TSHRLMNAKMT2AL3MBTL1 | |
| SCHEMBL690646 | 0.82 | ALDH1A1 (0.38) | ALDH1A1TSHRLMNAKMT2AL3MBTL1 | |
| SCHEMBL690647 | 0.82 | ALDH1A1 (0.38) | ALDH1A1TSHRLMNAKMT2AL3MBTL1 | |
| SCHEMBL15746346 | 0.81 | ALDH1A1 (0.35) | ALDH1A1TSHRLMNAKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430015-B1 | FUSED TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME (US) | 2015-06-17 | — | — | EP | disclosed |