SCHEMBL16803249 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	CHEK1	O14757	1/20	0.32

▸	MAP2K2	P36507	1/20	0.32

▸	MAPK10	P53779	1/20	0.32

▸	PRKAG1	P54619	1/20	0.32

▸	MAP2K1	Q02750	1/20	0.32

▸	ADCK1	Q86TW2	1/20	0.32

▸	PRKAG2	Q9UGJ0	1/20	0.32

▸	CNR2	P34972	1/20	0.30

▸	LMNA	P02545	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL16803245	0.82	BRAF (0.37)	CNR2
SCHEMBL1342335	0.75	CSF1R (0.32)	CHEK1MAP2K2MAPK10PRKAG1MAP2K1
SCHEMBL19050836	0.69	MAP2K1 (0.45)	CHEK1MAP2K2MAPK10PRKAG1MAP2K1
SCHEMBL14016189	0.68	MAP2K1 (0.36)	CHEK1MAP2K2MAPK10PRKAG1MAP2K1
SCHEMBL391581	0.65	MAP2K1 (0.55)	CHEK1MAP2K2MAPK10PRKAG1MAP2K1
SCHEMBL9995002	0.64	MAP2K1 (0.44)	CHEK1MAP2K2MAPK10PRKAG1MAP2K1
SCHEMBL13114870	0.64	MAP2K1 (0.37)	CHEK1MAP2K2MAPK10PRKAG1MAP2K1
SCHEMBL12763595	0.63	MAP2K1 (0.39)	MAP2K2MAP2K1
SCHEMBL1516492	0.63	MAP2K1 (0.38)	CHEK1MAP2K2MAPK10PRKAG1MAP2K1
SCHEMBL1516555	0.63	MAP2K1 (0.42)	MAP2K2MAP2K1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2121620-B1	INHIBITORS OF MEK	ARDEA BIOSCIENCES INC (US)	2015-06-17	—	—	EP	disclosed