SCHEMBL16807274

SCHEMBL16807274

Cc1ccc(C(C(=O)c2ccc(Cl)cc2)c2ccccc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 5/20 0.59
TDP1 Q9NUW8 1/20 0.59
POLB P06746 2/20 0.56
CES2 O00748 3/20 0.53
CES1 P23141 3/20 0.53
LMNA P02545 2/20 0.47
TP53 P04637 1/20 0.47
CNR1 P21554 2/20 0.46
CNR2 P34972 1/20 0.46
PTPN1 P18031 1/20 0.46
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
NTSR1 P30989 1/20 0.44
KDM4E B2RXH2 1/20 0.43
GAA P10253 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16781984 0.92 L3MBTL1 (0.70) L3MBTL1TDP1POLBCES2CES1
SCHEMBL15105761 0.90 L3MBTL1 (0.73) L3MBTL1TDP1CES2CES1LMNA
SCHEMBL2928039 0.88 L3MBTL1 (0.77) L3MBTL1TDP1POLBCES2CES1
SCHEMBL16807280 0.88 L3MBTL1 (0.56) L3MBTL1TDP1POLBCES2CES1
SCHEMBL16807276 0.86 L3MBTL1 (0.54) L3MBTL1TDP1POLBCES2CES1
SCHEMBL16781997 0.86 L3MBTL1 (0.73) L3MBTL1TDP1POLBCES2CES1
SCHEMBL7589819 0.86 L3MBTL1 (0.73) L3MBTL1TDP1CES2CES1LMNA
SCHEMBL11605838 0.84 L3MBTL1 (0.70) L3MBTL1TDP1POLBCES2CES1
SCHEMBL16781983 0.84 L3MBTL1 (0.56) L3MBTL1TDP1POLBCES2CES1
SCHEMBL16781988 0.84 TDP1 (0.59) L3MBTL1TDP1CES2CES1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9656947-B2 Process for creating carbon-carbon bonds using carbonyl compounds CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (FR) 2017-05-23 US disclosed
US-9656947-B2 Process for creating carbon-carbon bonds using carbonyl compounds CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (FR) 2017-05-23 US disclosed
EP-2858966-B1 PROCESS FOR CREATING CARBON-CARBON BONDS USING CARBONYL COMPOUNDS CENTRE NAT RECH SCIENT (FR) 2016-08-10 EP disclosed
US-20150166464-A1 PROCESS FOR CREATING CARBON-CARBON BONDS USING CARBONYL COMPOUNDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N. R.S.) (FR) 2015-06-18 US disclosed
US-20150166464-A1 PROCESS FOR CREATING CARBON-CARBON BONDS USING CARBONYL COMPOUNDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N. R.S.) (FR) 2015-06-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150166464-A1 PROCESS FOR CREATING CARBON-CARBON BONDS USING CARBONYL COMPOUNDS CBR3, CBR1, CYP4F3 L3MBTL1 4386/4885TDP1 4876/4885POLB 2802/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.