Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCKR | Q14397 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17471 | 0.99 | — | — | |
| SCHEMBL17125 | 0.82 | — | — | |
| SCHEMBL16867 | 0.79 | GCKR (0.33) | GCKR | |
| Hydrochloric Acid SCHEMBL23484 | 0.78 | GCKR (0.33) | GCKR | |
| SCHEMBL12078539 | 0.78 | CYP3A4 (0.40) | — | |
| SCHEMBL16420 | 0.77 | CA1 (0.41) | — | |
| Hydrochloric Acid SCHEMBL16218 | 0.77 | CYP3A4 (0.40) | — | |
| SCHEMBL12077490 | 0.73 | CTSL (0.34) | — | |
| SCHEMBL16814 | 0.73 | — | — | |
| SCHEMBL22891 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |