Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.38 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16793052 | 0.81 | TPH1 (0.42) | TPH1EGLN2CYP2E1CYP2A6PSEN1 | |
| SCHEMBL27768055 | 0.75 | CYP2E1 (0.45) | EGLN2CYP2E1CYP2A6PSEN1PSEN2 | |
| SCHEMBL15633080 | 0.74 | CYP2E1 (0.47) | EGLN2CYP2E1CYP2A6PSEN1PSEN2 | |
| SCHEMBL11781816 | 0.74 | PSEN1 (0.48) | TPH1EGLN2PSEN1PSEN2APH1B | |
| SCHEMBL27159701 | 0.71 | CYP1A2 (0.51) | EGLN2CYP2E1CYP2A6PSEN1PSEN2 | |
| SCHEMBL27819262 | 0.71 | GAA (0.48) | EGLN2CYP2E1CYP2A6PSEN1PSEN2 | |
| SCHEMBL27417595 | 0.71 | CYP2E1 (0.45) | EGLN2CYP2E1CYP2A6PSEN1PSEN2 | |
| SCHEMBL27747138 | 0.71 | CYP2E1 (0.45) | EGLN2CYP2E1CYP2A6PSEN1PSEN2 | |
| SCHEMBL22199076 | 0.71 | PHF8 (0.51) | EGLN2CYP2E1CYP2A6PSEN1PSEN2 | |
| SCHEMBL2824693 | 0.71 | KDM4E (0.50) | EGLN2CYP2E1CYP2A6PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |