Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.80 |
| ▸ | FLT3 | P36888 | 18/20 | 0.80 |
| ▸ | CSF1R | P07333 | 9/20 | 0.80 |
| ▸ | FLT4 | P35916 | 9/20 | 0.80 |
| ▸ | PLK4 | O00444 | 5/20 | 0.80 |
| ▸ | AURKA | O14965 | 5/20 | 0.80 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.80 |
| ▸ | MET | P08581 | 5/20 | 0.80 |
| ▸ | PRKACA | P17612 | 5/20 | 0.80 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.80 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.80 |
| ▸ | STK3 | Q13188 | 5/20 | 0.80 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.80 |
| ▸ | MARK2 | Q7KZI7 | 5/20 | 0.80 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.80 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.80 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.80 |
| ▸ | CDK1 | P06493 | 4/20 | 0.80 |
| ▸ | MARK3 | P27448 | 4/20 | 0.80 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Linifanib SCHEMBL2239943 | 0.89 | KDR (0.94) | KDRFLT3CSF1RFLT4PLK4 | |
| SCHEMBL422640 | 0.89 | KDR (1.00) | KDRFLT3CSF1RFLT4PLK4 | |
| SCHEMBL423819 | 0.89 | KDR (0.82) | KDRFLT3CSF1RFLT4PLK4 | |
| Linifanib SCHEMBL29375368 | 0.86 | KDR (1.00) | KDRFLT3CSF1RFLT4PLK4 | |
| Linifanib SCHEMBL93804 | 0.86 | KDR (1.00) | KDRFLT3CSF1RFLT4PLK4 | |
| Alcohol SCHEMBL16817141 | 0.86 | KDR (0.81) | KDRFLT3CSF1RFLT4PLK4 | |
| Linifanib SCHEMBL1880038 | 0.85 | KDR (0.98) | KDRFLT3CSF1RFLT4PLK4 | |
| SCHEMBL422778 | 0.85 | KDR (1.00) | KDRFLT3CSF1RFLT4PLK4 | |
| SCHEMBL1662335 | 0.85 | KDR (0.81) | KDRFLT3CSF1RFLT4PLK4 | |
| SCHEMBL27825511 | 0.85 | KDR (0.88) | KDRFLT3CSF1RFLT4PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195300-B1 | CRYSTALLINE CHEMOTHERAPEUTIC | ABBVIE BAHAMAS LTD (BS) | 2015-06-24 | — | — | EP | disclosed |