Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 7/20 | 0.42 |
| ▸ | BTK | Q06187 | 5/20 | 0.42 |
| ▸ | PLCG1 | P19174 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723514 | 0.87 | EGFR (0.47) | JAK3EGFRBTKPLCG1TDP2 | |
| SCHEMBL723785 | 0.84 | BTK (0.56) | JAK3EGFRBTKPLCG1 | |
| SCHEMBL722213 | 0.83 | BTK (0.59) | JAK3EGFRBTK | |
| SCHEMBL723014 | 0.83 | EGFR (0.58) | JAK3EGFRBTK | |
| SCHEMBL722390 | 0.82 | BTK (0.49) | JAK3EGFRBTK | |
| SCHEMBL722377 | 0.81 | EGFR (0.49) | JAK3EGFRBTKFGFR4 | |
| SCHEMBL723264 | 0.77 | PLCG1 (0.51) | JAK3EGFRBTKPLCG1 | |
| SCHEMBL721787 | 0.77 | TGM2 (0.52) | JAK3EGFRBTK | |
| SCHEMBL723354 | 0.74 | EGFR (0.45) | EGFRBTKPLCG1FGFR4 | |
| SCHEMBL721852 | 0.73 | BTK (0.47) | JAK3EGFRBTKJAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | claimed |