Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | SYK | P43405 | 5/20 | 0.59 |
| ▸ | CD63 | P08962 | 2/20 | 0.59 |
| ▸ | MAPKAPK5 | Q8IW41 | 11/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | ROS1 | P08922 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.55 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.55 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | YES1 | P07947 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.50 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27359522 | 0.85 | ADRB2 (0.47) | AURKASYKCD63MAPKAPK5NTRK1 | |
| SCHEMBL20005722 | 0.84 | AURKA (0.65) | AURKASYKCD63NTRK1JAK2 | |
| SCHEMBL2482275 | 0.83 | AURKA (0.79) | AURKASYKCD63NTRK1JAK2 | |
| SCHEMBL23911850 | 0.80 | AURKA (0.81) | AURKASYKCD63NTRK1JAK2 | |
| SCHEMBL11939508 | 0.80 | MAPKAPK5 (0.61) | AURKAMAPKAPK5NTRK1FYNABL1 | |
| SCHEMBL18472053 | 0.80 | AURKA (0.61) | AURKASYKCD63MAPKAPK5NTRK1 | |
| SCHEMBL1673999 | 0.80 | MAPKAPK5 (0.67) | AURKASYKCD63MAPKAPK5FYN | |
| SCHEMBL5574908 | 0.79 | MAPKAPK5 (0.65) | AURKASYKCD63MAPKAPK5FYN | |
| SCHEMBL5571657 | 0.78 | MAPKAPK5 (0.72) | AURKASYKCD63MAPKAPK5JAK2 | |
| SCHEMBL2482747 | 0.78 | AURKA (0.77) | AURKASYKCD63NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9931338-B2 | Syk inhibitors | GILEAD SCIENCES, INC. (US) | 2018-04-03 | — | — | US | disclosed |
| US-20170035755-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2017-02-09 | — | — | US | disclosed |
| US-9290505-B2 | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors | GILEAD SCIENCES, INC. (US) | 2016-03-22 | — | — | US | disclosed |
| US-20150175616-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2015-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170035755-A1 | SYK INHIBITORS | SYK, BTK, LYN | AURKA 295/4885SYK 1/4885CD63 2809/4885 |
| US-20150175616-A1 | SYK INHIBITORS | SYK, BTK, LYN | AURKA 711/4885SYK 1/4885CD63 2113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.