Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 8/20 | 0.44 |
| ▸ | NOS1 | P29475 | 8/20 | 0.44 |
| ▸ | NOS3 | P29474 | 6/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL10585913 | 1.00 | OTC (0.46) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL19462254 | 1.00 | OTC (0.46) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL15323659 | 0.97 | OTC (0.43) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL15323660 | 0.97 | OTC (0.43) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL3633342 | 0.95 | OTC (0.42) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL3633339 | 0.95 | OTC (0.42) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL27161043 | 0.95 | OTC (0.42) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL2787541 | 0.94 | OTC (0.50) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL5544125 | 0.94 | OTC (0.50) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL5312506 | 0.94 | OTC (0.50) | OTCNOS2NOS1NOS3DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056047-A2 | ANTIBODIES, ASSAYS AND KITS TO QUANTITATE CARTILAGE DESTRUCTION | ARTICULAR ENGINEERING, LLC. (US) | 2007-05-18 | — | — | WO | claimed |
| US-20070099246-A1 | Antibodies, assays and kits to quantitate cartilage destruction | SANDY JOHN D | 2007-05-03 | — | — | US | claimed |
| EP-3443346-A1 | USE OF AMINO ACIDS AS STABILIZING COMPOUNDS IN PHARMACEUTICAL COMPOSITIONS CONTAINING HIGH CONCENTRATIONS OF PROTEIN-BASED THERAPEUTIC AGENTS | Medimmune, LLC (US) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017180594-A1 | USE OF AMINO ACIDS AS STABILIZING COMPOUNDS IN PHARMACEUTICAL COMPOSITIONS CONTAINING HIGH CONCENTRATIONS OF PROTEIN-BASED THERAPEUTIC AGENTS | MEDIMMUNE, LLC (US) | 2017-10-19 | — | — | WO | disclosed |
| EP-2488550-A2 | MUTANT LOW-DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN WITH INCREASED BINDING TO ALZHEIMER AMYLOID-BETA PEPTIDE | ZZ Alztech LLC (US) | 2012-08-22 | — | — | EP | disclosed |
| US-20120201757-A1 | MUTANT LOW-DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN WITH INCREASED BINDING TO ALZHEIMER AMYLOID-BETA PEPTIDE | ZZ ALZTECH, L.L.C. | 2012-08-09 | — | — | US | disclosed |
| WO-2011046622-A2 | MUTANT LOW-DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN WITH INCREASED BINDING TO ALZHEIMER AMYLOID-BETA PEPTIDE | ZZ ALZTECH L.L.C. (US) | 2011-04-21 | — | — | WO | disclosed |
| WO-2007056047-A2 | ANTIBODIES, ASSAYS AND KITS TO QUANTITATE CARTILAGE DESTRUCTION | ARTICULAR ENGINEERING, LLC. (US) | 2007-05-18 | — | — | WO | disclosed |
| US-20070099246-A1 | Antibodies, assays and kits to quantitate cartilage destruction | SANDY JOHN D | 2007-05-03 | — | — | US | disclosed |
| WO-2005103264-A1 | PROCESS FOR THE PREPARATION OF RECOMBINANT AMEDIPLASE | MENARINI BIOTECH S.R.L. (IT) | 2005-11-03 | — | — | WO | disclosed |
| EP-0805678-B1 | SURFACE-MODIFIED NANOPARTICLES AND METHOD OF MAKING AND USING SAME | UNIV MICHIGAN (US) | 2003-10-29 | — | — | EP | disclosed |
| EP-0805678-A1 | SURFACE-MODIFIED NANOPARTICLES AND METHOD OF MAKING AND USING SAME | THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN (US) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996020698-A2 | SURFACE-MODIFIED NANOPARTICLES AND METHOD OF MAKING AND USING SAME | THE BOARD OF REGENTS ACTING FOR AND ON BEHALF OF THE UNIVERSITY OF MICHIGAN (US) | 1996-07-11 | — | — | WO | disclosed |