Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 6/20 | 0.40 |
| ▸ | NOS1 | P29475 | 5/20 | 0.40 |
| ▸ | NOS3 | P29474 | 4/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | BHMT | Q93088 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | NPY4R | P50391 | 3/20 | 0.35 |
| ▸ | NPY1R | P25929 | 2/20 | 0.35 |
| ▸ | NPY2R | P49146 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL3633342 | 1.00 | OTC (0.42) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL16179489 | 0.96 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL4171389 | 0.96 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL16179227 | 0.96 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL15140178 | 0.96 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL27873762 | 0.96 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL3475256 | 0.95 | OTC (0.39) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL3692892 | 0.95 | OTC (0.39) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL4203993 | 0.95 | OTC (0.46) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL17550 | 0.95 | OTC (0.46) | OTCNOS2NOS1NOS3DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023170316-A1 | HYDROGEL SUITABLE TO PRODUCE ARTIFICIAL TISSUES | UNIVERSIDAD DE GRANADA (ES) | 2023-09-14 | — | — | WO | disclosed |
| EP-2150105-A2 | SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE USING LACTATE AS AN INDICATOR | Transmedics, Inc. (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008150587-A2 | SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE USING LACTATE AS AN INDICATOR | TRANSMEDICS, INC. (US) | 2008-12-11 | — | — | WO | disclosed |