Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.54 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.54 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16830145 | 1.00 | MAPK1 (0.62) | MAPK1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9681922 | 0.83 | ALDH1A1 (0.59) | MAPK1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11037350 | 0.82 | ALDH1A1 (0.65) | MAPK1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL4490833 | 0.81 | ALDH1A1 (0.68) | MAPK1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3271853 | 0.81 | ALDH1A1 (0.68) | MAPK1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1285405 | 0.79 | HTT (0.74) | MAPK1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL30168131 | 0.79 | HTT (0.74) | MAPK1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5520652 | 0.78 | MAPT (0.64) | MAPK1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL25356392 | 0.77 | MAPK1 (1.00) | MAPK1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL18702772 | 0.77 | MAPK1 (0.68) | MAPK1MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018109650-A1 | SPIRO[CYCLOPENTANE-1,3'-INDOLIN]-2'-ONE DERIVATIVES AS BROMODOMAIN INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-06-21 | — | — | WO | disclosed |
| WO-2015092118-A1 | SPIRO[CYCLOBUTANE-1,3'-INDOLIN]-2'-ONE DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORPORATION (FI) | 2015-06-25 | — | — | WO | disclosed |