Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 4/20 | 0.51 |
| ▸ | AXL | P30530 | 3/20 | 0.51 |
| ▸ | ULK1 | O75385 | 6/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1683410 | 0.81 | ULK1 (0.55) | CDK8AXLULK1PIK3CDPIK3CA | |
| Hydrochloric Acid SCHEMBL28886175 | 0.79 | ULK1 (0.53) | CDK8AXLULK1PIK3CDPIK3CA | |
| SCHEMBL878920 | 0.79 | ULK1 (0.52) | CDK8AXLULK1PIK3CDPIK3CA | |
| SCHEMBL878862 | 0.78 | ULK1 (0.51) | CDK8AXLULK1PIK3CDPIK3CA | |
| SCHEMBL856199 | 0.77 | CDK8 (0.60) | CDK8AXLULK1PIK3CDPIK3CA | |
| SCHEMBL1683432 | 0.77 | ABL1 (0.49) | CDK8AXLULK1PIK3CDPIK3CA | |
| SCHEMBL21779268 | 0.77 | ULK1 (0.48) | CDK8AXLULK1PIK3CDPIK3CA | |
| SCHEMBL29375909 | 0.77 | CDK8 (0.49) | CDK8AXLULK1PIK3CDPIK3CA | |
| SCHEMBL11886203 | 0.77 | CDK8 (0.47) | CDK8AXLULK1PIK3CDPIK3CA | |
| SCHEMBL297772 | 0.76 | CDK8 (0.55) | CDK8AXLPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539763-B1 | AZAINDOLE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-04-13 | — | — | EP | disclosed |