Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | SQOR | Q9Y6N5 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16847913 | 0.80 | ERBB2 (0.44) | CYP1A2CYP3A4CYP2C19ERBB2MEN1 | |
| SCHEMBL16847722 | 0.80 | LRRK2 (0.40) | CYP1A2CYP3A4CYP2C19ERBB2MEN1 | |
| SCHEMBL16855753 | 0.79 | AR (0.44) | CYP1A2CYP3A4CYP2C19ERBB2MEN1 | |
| SCHEMBL16834842 | 0.79 | ALOX5AP (0.46) | ERBB2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL1259949 | 0.78 | ALDH1A1 (0.44) | CYP1A2CYP3A4CYP2C19ERBB2MEN1 | |
| SCHEMBL16847946 | 0.78 | DYRK1A (0.33) | ALDH1A1CHUKLMNAADORA1ADORA2A | |
| SCHEMBL16847719 | 0.74 | SLC22A12 (0.43) | CYP1A2CYP2C19ERBB2MEN1KMT2A | |
| SCHEMBL16847912 | 0.73 | ALOX5AP (0.47) | CYP1A2CYP3A4CYP2C19ERBB2MEN1 | |
| SCHEMBL16834847 | 0.73 | ALDH1A1 (0.34) | ALDH1A1KDM4EHPGDLMNANPSR1 | |
| SCHEMBL31236710 | 0.72 | ERBB2 (0.41) | CYP1A2CYP3A4CYP2C19ERBB2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106795120-B | Novel pyridyloxy-and phenyloxy-pyrazolyl compounds | 豪夫迈·罗氏有限公司 | 2020-09-01 | — | — | CN | claimed |
| EP-3083605-B1 | FLUOROPHENYL PYRAZOL COMPOUNDS | LILLY CO ELI (US) | 2018-02-21 | — | — | EP | disclosed |
| EP-3083605-B1 | FLUOROPHENYL PYRAZOL COMPOUNDS | LILLY CO ELI (US) | 2018-02-21 | — | — | EP | disclosed |
| US-9499490-B2 | Fluorophenyl pyrazol compounds | ELI LILLY AND COMPANY (US) | 2016-11-22 | — | — | US | disclosed |
| US-9499490-B2 | Fluorophenyl pyrazol compounds | ELI LILLY AND COMPANY (US) | 2016-11-22 | — | — | US | disclosed |
| US-9499490-B2 | Fluorophenyl pyrazol compounds | ELI LILLY AND COMPANY (US) | 2016-11-22 | — | — | US | disclosed |
| EP-3083605-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | Eli Lilly & Company (US) | 2016-10-26 | — | — | EP | disclosed |
| US-20160289195-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY | 2016-10-06 | — | — | US | disclosed |
| US-20160289195-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY | 2016-10-06 | — | — | US | disclosed |
| US-20160289195-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY | 2016-10-06 | — | — | US | disclosed |
| WO-2015094913-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015094913-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015089800-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015089800-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160289195-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | SLCO1B3, CYP3A43, CYP4F3 | CYP1A2 78/4885CYP3A4 32/4885CYP2C19 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.