Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 10/20 | 0.38 |
| ▸ | VEGFA | P15692 | 6/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16855756 | 0.88 | ERBB2 (0.39) | ERBB2EPAS1VEGFAKDM1A | |
| SCHEMBL16847910 | 0.85 | EPAS1 (0.42) | ERBB2EPAS1VEGFA | |
| SCHEMBL16834858 | 0.84 | SLC22A12 (0.41) | SLC22A12NPY5RERBB2EPAS1VEGFA | |
| SCHEMBL16834851 | 0.81 | PRMT5 (0.36) | CYP11B1CYP11B2EPAS1 | |
| SCHEMBL16847723 | 0.78 | PRMT5 (0.43) | — | |
| SCHEMBL16847912 | 0.78 | ALOX5AP (0.47) | NPY5RCYP3A4ERBB2 | |
| SCHEMBL16834960 | 0.78 | SLC22A12 (0.41) | SLC22A12ERBB2KDM1A | |
| SCHEMBL2425876 | 0.77 | CYP3A4 (0.50) | SLC22A12NPY5RCYP3A4CHRNB2CHRNA4 | |
| SCHEMBL16847721 | 0.77 | MAP2K4 (0.43) | NPY5REPAS1 | |
| SCHEMBL16855753 | 0.77 | AR (0.44) | SLC22A12CYP3A4ERBB2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106795120-B | Novel pyridyloxy-and phenyloxy-pyrazolyl compounds | 豪夫迈·罗氏有限公司 | 2020-09-01 | — | — | CN | claimed |
| EP-3083605-B1 | FLUOROPHENYL PYRAZOL COMPOUNDS | LILLY CO ELI (US) | 2018-02-21 | — | — | EP | disclosed |
| EP-3083605-B1 | FLUOROPHENYL PYRAZOL COMPOUNDS | LILLY CO ELI (US) | 2018-02-21 | — | — | EP | disclosed |
| US-9499490-B2 | Fluorophenyl pyrazol compounds | ELI LILLY AND COMPANY (US) | 2016-11-22 | — | — | US | disclosed |
| US-9499490-B2 | Fluorophenyl pyrazol compounds | ELI LILLY AND COMPANY (US) | 2016-11-22 | — | — | US | disclosed |
| US-9499490-B2 | Fluorophenyl pyrazol compounds | ELI LILLY AND COMPANY (US) | 2016-11-22 | — | — | US | disclosed |
| EP-3083605-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | Eli Lilly & Company (US) | 2016-10-26 | — | — | EP | disclosed |
| US-20160289195-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY | 2016-10-06 | — | — | US | disclosed |
| US-20160289195-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY | 2016-10-06 | — | — | US | disclosed |
| US-20160289195-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY | 2016-10-06 | — | — | US | disclosed |
| WO-2015094913-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015094913-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015089800-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160289195-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | SLCO1B3, CYP3A43, CYP4F3 | SLC22A12 681/4885NPY5R 126/4885CYP3A4 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.