Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | VEGFA | P15692 | 2/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2422932 | 0.87 | CHRNB2 (0.48) | CYP3A4CYP19A1SLC22A12CHRNB2CHRNA4 | |
| SCHEMBL30689372 | 0.83 | CYP19A1 (0.57) | CYP3A4CYP19A1SLC22A12GRM5CYP11B1 | |
| SCHEMBL27368527 | 0.83 | CYP19A1 (0.57) | CYP3A4CYP19A1SLC22A12GRM5CYP11B1 | |
| SCHEMBL6821689 | 0.83 | CYP19A1 (0.56) | CYP3A4CYP19A1SLC22A12CHRNB2CHRNA4 | |
| SCHEMBL876009 | 0.80 | CYP19A1 (0.45) | CYP3A4CYP19A1GRM5VEGFAEPAS1 | |
| SCHEMBL876496 | 0.80 | LTA4H (0.46) | CYP3A4CYP19A1GRM5CYP11B1CYP11B2 | |
| SCHEMBL3138833 | 0.78 | PARP15 (0.53) | CYP3A4CYP19A1CYP1A2CYP2C19KDM4E | |
| SCHEMBL16834849 | 0.77 | SLC22A12 (0.43) | CYP3A4SLC22A12CHRNB2CHRNA4NPY5R | |
| SCHEMBL2196501 | 0.77 | CYP19A1 (0.71) | CYP19A1GRM5CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL923535 | 0.76 | ALOX5 (0.50) | CYP3A4CYP19A1SLC22A12CYP1A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011117254-A1 | PIPERIDINE AMIDES AS MODULATORS OF THE GHRELIN RECEPTOR | PROSIDION LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |