Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 17/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 13/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16834854 | 1.00 | CYP11B1 (0.53) | CYP11B1CYP11B2HTR7CYP1A2CYP2C19 | |
| SCHEMBL16834855 | 1.00 | CYP11B1 (0.53) | CYP11B1CYP11B2HTR7CYP1A2CYP2C19 | |
| SCHEMBL16855807 | 0.89 | CYP11B1 (0.49) | CYP11B1CYP11B2HTR7 | |
| SCHEMBL18107156 | 0.77 | CYP11B1 (0.43) | CYP11B1CYP11B2CYP1A2CYP2C19 | |
| SCHEMBL16847894 | 0.77 | CYP11B1 (0.43) | CYP11B1CYP11B2CYP1A2CYP2C19 | |
| SCHEMBL18107164 | 0.75 | CYP11B1 (0.49) | CYP11B1CYP11B2 | |
| SCHEMBL16847686 | 0.75 | CYP11B1 (0.49) | CYP11B1CYP11B2 | |
| SCHEMBL18107975 | 0.74 | CYP11B1 (0.43) | CYP11B1CYP11B2 | |
| SCHEMBL16847973 | 0.74 | CYP11B1 (0.43) | CYP11B1CYP11B2 | |
| SCHEMBL16834841 | 0.72 | CYP11B1 (0.49) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083605-B1 | FLUOROPHENYL PYRAZOL COMPOUNDS | LILLY CO ELI (US) | 2018-02-21 | — | — | EP | disclosed |
| EP-3083605-B1 | FLUOROPHENYL PYRAZOL COMPOUNDS | LILLY CO ELI (US) | 2018-02-21 | — | — | EP | disclosed |
| US-9499490-B2 | Fluorophenyl pyrazol compounds | ELI LILLY AND COMPANY (US) | 2016-11-22 | — | — | US | disclosed |
| US-9499490-B2 | Fluorophenyl pyrazol compounds | ELI LILLY AND COMPANY (US) | 2016-11-22 | — | — | US | disclosed |
| US-9499490-B2 | Fluorophenyl pyrazol compounds | ELI LILLY AND COMPANY (US) | 2016-11-22 | — | — | US | disclosed |
| EP-3083605-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | Eli Lilly & Company (US) | 2016-10-26 | — | — | EP | disclosed |
| US-20160289195-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY | 2016-10-06 | — | — | US | disclosed |
| US-20160289195-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY | 2016-10-06 | — | — | US | disclosed |
| US-20160289195-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY | 2016-10-06 | — | — | US | disclosed |
| WO-2015089800-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015094913-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160289195-A1 | FLUOROPHENYL PYRAZOL COMPOUNDS | SLCO1B3, CYP3A43, CYP4F3 | CYP11B1 40/4885CYP11B2 20/4885HTR7 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.