Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 8/20 | 0.66 |
| ▸ | PDE1A | P54750 | 5/20 | 0.66 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.66 |
| ▸ | PDE5A | O76074 | 10/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | PDE8B | O95263 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.51 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30808243 | 0.80 | EGFR (0.59) | PDE1BPDE1APDE1CPDE5AKDM4E | |
| SCHEMBL22435106 | 0.80 | PDE1B (1.00) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL12844112 | 0.78 | PDE1B (0.55) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL30605542 | 0.77 | PDE1B (0.54) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL857052 | 0.77 | PDE1B (0.54) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL12775446 | 0.74 | PDE1B (0.51) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL12843989 | 0.74 | PDE1B (0.58) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL12141932 | 0.74 | PDE1B (0.61) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL16822558 | 0.74 | PDE1B (0.51) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL16822617 | 0.74 | PDE1B (0.51) | PDE1BPDE1APDE1CPDE5APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105829300-B | Quinazoline-THF- amine as PDE1 inhibitor | H.隆德贝克有限公司 | 2019-03-15 | — | — | CN | disclosed |
| US-10030007-B2 | Quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2018-07-24 | — | — | US | disclosed |
| US-20170267664-A1 | Quinazolin-THF-Amines as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2017-09-21 | — | — | US | disclosed |
| US-9701665-B2 | Quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2017-07-11 | — | — | US | disclosed |
| US-20160318910-A1 | Quinazolin-THF-Amines as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2016-11-03 | — | — | US | disclosed |
| EP-3083607-A1 | QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. Lundbeck A/S (DK) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015091805-A1 | QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10030007-B2 | Quinazolin-THF-amines as PDE1 inhibitors | PDE12, PDE3A, PDE5A | PDE1B 15/4885PDE1A 12/4885PDE1C 29/4885 |
| US-20160318910-A1 | Quinazolin-THF-Amines as PDE1 Inhibitors | PDE12, PDE3A, PDE5A | PDE1B 15/4885PDE1A 13/4885PDE1C 29/4885 |
| US-20170267664-A1 | Quinazolin-THF-Amines as PDE1 Inhibitors | PDE12, PDE3A, PDE5A | PDE1B 15/4885PDE1A 12/4885PDE1C 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.