Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16835554 | 0.80 | PDE1B (0.66) | ALDH1A1HSD17B10CYP1A2CYP3A4TDP1 | |
| SCHEMBL29853721 | 0.79 | PDE5A (0.53) | EGFRALDH1A1HSD17B10KDM4EMAPK1 | |
| SCHEMBL9206939 | 0.79 | EGFR (0.66) | EGFRALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL9214074 | 0.77 | EGFR (0.64) | EGFRALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL1039877 | 0.77 | HTR1A (0.56) | EGFRALDH1A1HSD17B10LMNAKDM4E | |
| SCHEMBL31152241 | 0.77 | PDE5A (0.43) | ALDH1A1HSD17B10CYP1A2CYP3A4LMNA | |
| SCHEMBL14843241 | 0.77 | PDE5A (0.43) | ALDH1A1HSD17B10CYP1A2CYP3A4LMNA | |
| SCHEMBL3240985 | 0.77 | HTR1A (0.50) | EGFRALDH1A1CYP1A2CYP2C19HPGD | |
| SCHEMBL11583026 | 0.77 | HTR1A (0.50) | EGFRALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL20813844 | 0.75 | HTR1A (0.49) | EGFRHPGDHTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113039182-B | Inhibitors of YAP/TAZ-TEAD interactions and their use in cancer treatment | 伊文蒂瓦公司 | 2024-02-20 | — | — | CN | disclosed |