Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.47 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.47 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.47 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.46 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28407878 | 0.99 | ALDH1A1 (0.54) | ALDH1A1TAAR1GPR84IDO1POLB | |
| SCHEMBL3467183 | 0.99 | ALDH1A1 (0.54) | ALDH1A1TAAR1GPR84IDO1POLB | |
| SCHEMBL10696885 | 0.99 | ALDH1A1 (0.54) | ALDH1A1TAAR1GPR84IDO1POLB | |
| SCHEMBL9229885 | 0.99 | ALDH1A1 (0.54) | ALDH1A1TAAR1GPR84IDO1POLB | |
| SCHEMBL17351649 | 0.99 | ALDH1A1 (0.54) | ALDH1A1TAAR1GPR84IDO1POLB | |
| SCHEMBL2679996 | 0.97 | ALDH1A1 (0.55) | ALDH1A1TAAR1GPR84IDO1POLB | |
| SCHEMBL29405275 | 0.97 | ALDH1A1 (0.55) | ALDH1A1TAAR1GPR84IDO1POLB | |
| SCHEMBL6753938 | 0.93 | ALDH1A1 (0.60) | ALDH1A1TAAR1IDO1POLBNPC1 | |
| SCHEMBL6756155 | 0.86 | TAAR1 (0.56) | ALDH1A1TAAR1IDO1POLBNPC1 | |
| SCHEMBL7854778 | 0.85 | ALDH1A1 (0.55) | ALDH1A1TAAR1IDO1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 125 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3463333-A1 | A PROCESS FOR THE PREPARATION OF ELUXADOLINE | Sun Pharmaceutical Industries Limited (IN) | 2019-04-10 | — | — | EP | claimed |
| WO-2017208156-A1 | A PROCESS FOR THE PREPARATION OF ELUXADOLINE | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2017-12-07 | — | — | WO | claimed |
| US-12441910-B2 | Silicone-based barrier compositions | DOW GLOBAL TECHNOLOGIES LLC (US) | 2025-10-14 | — | — | US | disclosed |
| US-20250250457-A1 | COATING COMPOSITION AND USE THEREOF | DOW SILICONES CORP (US) | 2025-08-07 | — | — | US | disclosed |
| EP-4504840-A1 | COATING COMPOSITION AND USE THEREOF | Dow Silicones Corporation (US) | 2025-02-12 | — | — | EP | disclosed |
| US-12209201-B2 | Silicone-based barrier compositions | ROHM AND HAAS COMPANY (US) | 2025-01-28 | — | — | US | disclosed |
| US-20240400779-A1 | SILICONE FOAM COMPOSITION | DOW GLOBAL TECHNOLOGIES LLC (US) | 2024-12-05 | — | — | US | disclosed |
| US-12129393-B2 | Binder composition and use thereof | DOW SILICONES CORPORATION (US) | 2024-10-29 | — | — | US | disclosed |
| US-20240343875-A1 | THE PREPARATION OF FOAMED SILICONE PRODUCTS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2024-10-17 | — | — | US | disclosed |
| US-20240327588-A1 | SILICONE FOAM COMPOSITION | DOW GLOBAL TECHNOLOGIES LLC (US) | 2024-10-03 | — | — | US | disclosed |
| EP-4384569-A1 | THE PREPARATION OF FOAMED SILICONE PRODUCTS | Dow Global Technologies LLC (US) | 2024-06-19 | — | — | EP | disclosed |
| EP-0739928-A2 | Crosslinked emulsions with optimum consistency and handling without thickeners | DOW CORNING CORPORATION (US) | 1996-10-30 | — | — | EP | disclosed |
| EP-0739947-A2 | Elastomers from silicone emulsions having self-catalytic crosslinkers | DOW CORNING CORPORATION (US) | 1996-10-30 | — | — | EP | disclosed |
| EP-0459501-B1 | Use of silicone emulsions in the web printing process | DOW CORNING (US) | 1994-12-21 | — | — | EP | disclosed |
| EP-0463431-A2 | Process for making polysiloxane emulsions | DOW CORNING CORPORATION (US) | 1992-01-02 | — | — | EP | disclosed |
| EP-0460683-A2 | Silicone mechanical emulsions for hair care | DOW CORNING CORPORATION (US) | 1991-12-11 | — | — | EP | disclosed |
| EP-0459500-A2 | Method for making polysiloxane emulsions | DOW CORNING CORPORATION (US) | 1991-12-04 | — | — | EP | disclosed |
| EP-0459501-A1 | Use of silicone emulsions in the web printing process | DOW CORNING CORPORATION (US) | 1991-12-04 | — | — | EP | disclosed |
| US-5064694-A | Antistatic, antimarring; cationic and anionic surfactants | DOW CORNING CORPORATION (US) | 1991-11-12 | — | — | US | disclosed |
| US-4062796-A | CATIONIC SURFACTANT, SODIUM ACRYLATE HOMOPOLYMER | HALLIBURTON COMPANY (US) | 1977-12-13 | — | — | US | disclosed |