Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 8/20 | 0.46 |
| ▸ | PDE1A | P54750 | 6/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.46 |
| ▸ | PDE5A | O76074 | 13/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PDE8B | O95263 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.31 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16822604 | 0.86 | PDE1B (0.61) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL20924052 | 0.86 | PDE1B (0.48) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL17142266 | 0.79 | PDE1B (0.48) | PDE1BPDE1APDE1CPDE5APDE4B | |
| SCHEMBL17142268 | 0.79 | PDE1B (0.48) | PDE1BPDE1APDE1CPDE5APDE4B | |
| SCHEMBL17142281 | 0.74 | EGFR (0.48) | PDE1BPDE1APDE1C | |
| SCHEMBL20913250 | 0.70 | PDE1B (0.53) | PDE1BPDE1APDE1CPDE4BJAK2 | |
| SCHEMBL16822550 | 0.65 | PDE1B (0.51) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL16822569 | 0.65 | PDE1B (0.53) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL16822553 | 0.63 | PDE1B (1.00) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL20924188 | 0.60 | PDE1B (0.37) | PDE1BPDE1APDE1CPDE5APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150175584-A1 | Quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2015-06-25 | — | — | US | disclosed |
| US-20150175584-A1 | Quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2015-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175584-A1 | Quinazolin-THF-amines as PDE1 inhibitors | PDE12, PDE3A, PDE5A | PDE1B 15/4885PDE1A 13/4885PDE1C 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.