Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 7/20 | 0.48 |
| ▸ | PDE1A | P54750 | 6/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.48 |
| ▸ | PDE5A | O76074 | 8/20 | 0.32 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | PDE8B | O95263 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.32 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16822604 | 0.89 | PDE1B (0.61) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL16843084 | 0.86 | PDE1B (0.46) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL17142266 | 0.82 | PDE1B (0.48) | PDE1BPDE1APDE1CPDE5APDE4B | |
| SCHEMBL17142268 | 0.82 | PDE1B (0.48) | PDE1BPDE1APDE1CPDE5APDE4B | |
| SCHEMBL17142281 | 0.77 | EGFR (0.48) | PDE1BPDE1APDE1C | |
| SCHEMBL20924188 | 0.73 | PDE1B (0.37) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL20913250 | 0.72 | PDE1B (0.53) | PDE1BPDE1APDE1CPDE4B | |
| SCHEMBL16822550 | 0.68 | PDE1B (0.51) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL16822553 | 0.65 | PDE1B (1.00) | PDE1BPDE1APDE1CPDE5APDE2A | |
| SCHEMBL16822569 | 0.62 | PDE1B (0.53) | PDE1BPDE1APDE1CPDE5APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083607-B1 | QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2019-04-24 | — | — | EP | disclosed |