Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.45 |
| ▸ | DRD3 | P35462 | 7/20 | 0.44 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | DRD5 | P21918 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16844594 | 0.84 | DRD2 (0.45) | DRD2DRD3HTR1DDRD4HTR5A | |
| SCHEMBL16844578 | 0.79 | MAPT (0.47) | — | |
| SCHEMBL16844572 | 0.79 | CA12 (0.44) | — | |
| SCHEMBL16844577 | 0.78 | TSHR (0.40) | DRD2DRD1 | |
| SCHEMBL16844574 | 0.74 | DRD2 (0.39) | DRD2 | |
| SCHEMBL1477386 | 0.73 | DRD2 (0.44) | DRD2DRD3HTR1DDRD4DRD1 | |
| SCHEMBL16844576 | 0.72 | CYP1A2 (0.37) | — | |
| SCHEMBL1477578 | 0.71 | TSHR (0.50) | — | |
| SCHEMBL22209851 | 0.71 | TSHR (0.50) | — | |
| SCHEMBL30280677 | 0.71 | TSHR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015095261-A1 | NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015089842-A1 | NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OSTEOPOROSIS | MERCK SHARP & DOHME CORP. (US) | 2015-06-25 | — | — | WO | disclosed |