Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937341 | 0.76 | KDM4E (0.46) | MAPTPOLBHSD17B10PDE4DHDAC1 | |
| SCHEMBL16844608 | 0.75 | NPC1 (0.41) | MAPTPOLBNPC1XBP1RAB9A | |
| SCHEMBL16844642 | 0.75 | PTPN1 (0.43) | MAPTPOLBNPC1XBP1RAB9A | |
| SCHEMBL130948 | 0.74 | PDE4D (0.40) | MAPTPOLBNPC1XBP1RAB9A | |
| SCHEMBL16865538 | 0.71 | NPC1 (0.40) | NPC1RAB9APDE4DIDO1ALOX5 | |
| SCHEMBL15989623 | 0.71 | ALDH1A1 (0.47) | MAPTPOLBNPC1XBP1RAB9A | |
| SCHEMBL30937334 | 0.70 | PTPN1 (0.37) | MAPTPOLBNPC1XBP1RAB9A | |
| SCHEMBL29245040 | 0.70 | PTPN1 (0.37) | MAPTPOLBNPC1XBP1RAB9A | |
| SCHEMBL29245023 | 0.69 | HSD17B10 (0.43) | MAPTNPC1RAB9AHSD17B10KDM4E | |
| SCHEMBL29245138 | 0.69 | PTPN1 (0.37) | PDE4DPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015095261-A1 | NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015089842-A1 | NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OSTEOPOROSIS | MERCK SHARP & DOHME CORP. (US) | 2015-06-25 | — | — | WO | disclosed |