Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.98 |
| ▸ | GAA | P10253 | 9/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.98 |
| ▸ | MEN1 | O00255 | 6/20 | 0.98 |
| ▸ | HTT | P42858 | 3/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.98 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.80 |
| ▸ | RAB9A | P51151 | 5/20 | 0.80 |
| ▸ | LMNA | P02545 | 4/20 | 0.80 |
| ▸ | HPGD | P15428 | 3/20 | 0.80 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | PKM | P14618 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL22817531 | 0.99 | GAA (1.00) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL1684415 | 0.90 | MAPT (0.80) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL1684711 | 0.89 | MAPT (1.00) | MAPTGAAALDH1A1KMT2AMEN1 | |
| Bromide SCHEMBL2340615 | 0.89 | MAPT (0.82) | MAPTGAAALDH1A1KMT2AMEN1 | |
| Bromide SCHEMBL18040788 | 0.88 | MAPT (0.98) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL12390656 | 0.88 | MAPT (1.00) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL1684795 | 0.88 | MAPT (0.77) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL1684657 | 0.87 | MAPT (0.84) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL1684579 | 0.87 | MAPT (0.84) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL12427000 | 0.87 | MAPT (0.84) | MAPTGAAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3111956-B1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2019-05-08 | — | — | EP | claimed |
| US-8680113-B2 | BMI-1 protein expression modulators | PTC THERAPEUTICS, INC. (US) | 2014-03-25 | — | — | US | claimed |
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2011-08-04 | — | — | US | claimed |
| EP-2306836-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC Therapeutics, Inc. (US) | 2011-04-13 | — | — | EP | claimed |
| WO-2010002985-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | claimed |
| WO-2008003511-A1 | USE OF AMINOTHIAZOLE DERIVATIVE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, IN THE TREATMENT OF DISEASES CHARACTERIZED BY ABNORMAL REPRESSION OF GENE TRANSCRIPTION, PARTICULARLY HUNTINGTON'S DISEASE | DIALECTICA S.R.L. (IT) | 2008-01-10 | — | — | WO | claimed |
| US-20220002296-A1 | PHARMACEUTICAL COMPOUNDS AND THERAPEUTIC METHODS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2022-01-06 | — | — | US | disclosed |
| US-10875861-B1 | Therapeutic compounds | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2020-12-29 | — | — | US | disclosed |
| EP-3111956-B1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2019-05-08 | — | — | EP | disclosed |
| EP-3111956-A1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC Therapeutics, Inc. (US) | 2017-01-04 | — | — | EP | disclosed |
| EP-2306836-B1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2016-09-07 | — | — | EP | disclosed |
| US-8680113-B2 | BMI-1 protein expression modulators | PTC THERAPEUTICS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2011-08-04 | — | — | US | disclosed |
| EP-2306836-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC Therapeutics, Inc. (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010002985-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
| WO-2008003511-A1 | USE OF AMINOTHIAZOLE DERIVATIVE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, IN THE TREATMENT OF DISEASES CHARACTERIZED BY ABNORMAL REPRESSION OF GENE TRANSCRIPTION, PARTICULARLY HUNTINGTON'S DISEASE | DIALECTICA S.R.L. (IT) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | BMI1, CREBBP, BAZ2A | MAPT 4026/4885GAA 3522/4885ALDH1A1 2357/4885 |
| US-10875861-B1 | Therapeutic compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, TP53, RB1 | MAPT 3759/4885GAA 3074/4885ALDH1A1 1847/4885 |
| US-20220002296-A1 | PHARMACEUTICAL COMPOUNDS AND THERAPEUTIC METHODS | BMI1, GLI1, MCL1 | MAPT 639/4885GAA 764/4885ALDH1A1 1412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.