Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 1/20 | 1.00 |
| ▸ | APBA1 | Q02410 | 1/20 | 1.00 |
| ▸ | KLF5 | Q13887 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.82 |
| ▸ | MAPT | P10636 | 6/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.82 |
| ▸ | LMNA | P02545 | 4/20 | 0.82 |
| ▸ | HTT | P42858 | 4/20 | 0.82 |
| ▸ | GAA | P10253 | 4/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.82 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.82 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.82 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.78 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.78 |
| ▸ | PIM1 | P11309 | 1/20 | 0.78 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.78 |
| ▸ | CDK2 | P24941 | 1/20 | 0.78 |
| ▸ | FLT4 | P35916 | 1/20 | 0.78 |
| ▸ | FLT3 | P36888 | 1/20 | 0.78 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL18040712 | 0.99 | CACNA1B (0.98) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| SCHEMBL29520697 | 0.90 | MAPT (1.00) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| SCHEMBL1684587 | 0.88 | CACNA1B (0.79) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| SCHEMBL1684637 | 0.88 | PRKD3 (1.00) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| Bromide SCHEMBL18040686 | 0.88 | CACNA1B (0.78) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| SCHEMBL1684910 | 0.87 | PRKD3 (0.78) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| Bromide SCHEMBL18040695 | 0.87 | PRKD3 (0.98) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| Bromide SCHEMBL18040767 | 0.86 | PRKD3 (0.77) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| SCHEMBL12789774 | 0.86 | MAPT (0.76) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| SCHEMBL1684729 | 0.85 | MAPT (0.79) | CACNA1BAPBA1KLF5KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306836-B1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2016-09-07 | — | — | EP | claimed |
| US-8680113-B2 | BMI-1 protein expression modulators | PTC THERAPEUTICS, INC. (US) | 2014-03-25 | — | — | US | claimed |
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2011-08-04 | — | — | US | claimed |
| EP-2306836-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC Therapeutics, Inc. (US) | 2011-04-13 | — | — | EP | claimed |
| WO-2010002985-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | claimed |
| EP-3111956-B1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2019-05-08 | — | — | EP | disclosed |
| EP-3111956-A1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC Therapeutics, Inc. (US) | 2017-01-04 | — | — | EP | disclosed |
| EP-2306836-B1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2016-09-07 | — | — | EP | disclosed |
| US-8680113-B2 | BMI-1 protein expression modulators | PTC THERAPEUTICS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | BMI1, CREBBP, BAZ2A | CACNA1B 4376/4885APBA1 1960/4885KLF5 689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.