Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 2/20 | 0.78 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.78 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | GAA | P10253 | 5/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.69 |
| ▸ | HTT | P42858 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.69 |
| ▸ | SYK | P43405 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | FLT4 | P35916 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1684587 | 0.99 | CACNA1B (0.79) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| SCHEMBL1684933 | 0.95 | CACNA1B (0.74) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| Bromide SCHEMBL18040712 | 0.89 | CACNA1B (0.98) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| SCHEMBL1684654 | 0.88 | CACNA1B (1.00) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| SCHEMBL1684431 | 0.87 | PRKD3 (0.74) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| SCHEMBL252991 | 0.85 | ALDH1A1 (0.66) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| SCHEMBL1684593 | 0.84 | MAPT (0.73) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| Bromide SCHEMBL18040728 | 0.82 | SYK (0.66) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| Bromide SCHEMBL18040673 | 0.82 | SYK (0.66) | CACNA1BAPBA1KLF5KDM4EMAPT | |
| Bromide SCHEMBL18040699 | 0.82 | SYK (0.66) | CACNA1BAPBA1KLF5KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3111956-B1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2019-05-08 | — | — | EP | disclosed |
| EP-3111956-A1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC Therapeutics, Inc. (US) | 2017-01-04 | — | — | EP | disclosed |
| EP-2306836-B1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2016-09-07 | — | — | EP | disclosed |