Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL5011203 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28346772 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL6716639 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL19349036 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2942784 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5909584 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL22734242 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL21494573 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL9478124 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4062662 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 627 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118033122-A | Preparation method for nanoparticle aggregation color development and simultaneous identification of meat component flow measuring strip | 华北理工大学 | 2024-05-14 | — | — | CN | claimed |
| EP-3743376-B1 | A METHOD FOR OBTAINING MESOPOROUS SILICA PARTICLES WITH SURFACE FUNCTIONALISATION | UNIV BERLIN TECH (DE) | 2024-03-06 | — | — | EP | claimed |
| CN-117506353-A | Manufacturing process of motorcycle engine cylinder block | 重庆市涪陵区源力气缸体有限公司 | 2024-02-06 | — | — | CN | claimed |
| WO-2023208133-A1 | CRYSTAL FORM OF BLARCAMESINE HYDROCHLORIDE, METHOD FOR PREPARING SAME, AND USE THEREOF | 苏州科睿思制药有限公司 | 2023-11-02 | — | — | WO | claimed |
| EP-4267139-A1 | ARIMOCLOMOL FOR THE TREATMENT OF NIEMANN PICK DISEASE, TYPE C, IN PATIENTS WITH ER TYPE MISSENSE MUTATIONS | Zevra Denmark A/S (DK) | 2023-11-01 | — | — | EP | claimed |
| CN-116836436-A | Hydrogel preparation method based on hofmeister effect and application of hydrogel in color-changing contact lens | 东南大学 | 2023-10-03 | — | — | CN | claimed |
| CN-112744916-B | Method for treating polluted water body by synchronous nitrification and denitrification biological carrier coupling system | 浙江海洋大学 | 2023-07-18 | — | — | CN | claimed |
| EP-4171559-A1 | ARIMOCLOMOL FOR TREATING GAUCHER DISEASE | Zevra Denmark A/S (DK) | 2023-05-03 | — | — | EP | claimed |
| CN-115784432-A | Improved integrated membrane bioreactor and cleaning method and application thereof | 南京环保产业创新中心有限公司 | 2023-03-14 | — | — | CN | claimed |
| CN-114133570-B | Self-repairing polysiloxane elastomer and preparation method thereof | 北京科技大学 | 2022-10-04 | — | — | CN | claimed |
| EP-0946143-A2 | A NITROIMIDAZOLE GEL COMPOSITION | BIOGLAN IRELAND (R & D) LIMITED (IE) | 1999-10-06 | — | — | EP | claimed |
| WO-1998027960-A2 | A NITROIMIDAZOLE GEL COMPOSITION | BIOGLAN IRELAND (R & D) LIMITED (IE) | 1998-07-02 | — | — | WO | claimed |
| EP-0435012-B1 | 2-part hair dyeing agent | SUNSTAR KK (JP) | 1994-04-27 | — | — | EP | claimed |
| US-5131912-A | Compound capable of forming bicarbonate by dissociation in water, alkali generating no irritating odor, hydrogen peroxide, buffer solution; ph control | SUNSTAR KABUSHIKI KAISHA (JP) | 1992-07-21 | — | — | US | claimed |
| EP-0435012-A1 | 2-part hair dyeing agent | SUNSTAR KABUSHIKI KAISHA (JP) | 1991-07-03 | — | — | EP | claimed |
| CN-1052043-A | 2-PART HAIR DYEING AGENTS | SUNSTAR KK (JP) | 1991-06-12 | — | — | CN | claimed |
| US-4652571-A | PARASYMPATHOMIMETIC AGENTS | NORTH CAROLINA STATE UNIVERSITY (US) | 1987-03-24 | — | — | US | claimed |
| EP-0172934-A1 | Microencapsulated naturally occuring pyrethrins | PENNWALT CORPORATION (US) | 1986-03-05 | — | — | EP | claimed |
| US-4497793-A | Microencapsulated naturally occuring pyrethrins | PENNWALT CORPORATION (US) | 1985-02-05 | — | — | US | claimed |
| EP-0069600-A2 | Pharmaceutical compositions | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1983-01-12 | — | — | EP | claimed |