Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.61 |
| ▸ | CASP1 | P29466 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 2/20 | 0.53 |
| ▸ | CASP7 | P55210 | 2/20 | 0.53 |
| ▸ | CASP6 | P55212 | 2/20 | 0.53 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.53 |
| ▸ | CTSL | P07711 | 4/20 | 0.51 |
| ▸ | CTSK | P43235 | 4/20 | 0.51 |
| ▸ | CTSS | P25774 | 3/20 | 0.51 |
| ▸ | CTSB | P07858 | 3/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.49 |
| ▸ | CASP9 | P55211 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7063703 | 0.86 | CASP1 (0.55) | SYKCASP1CASP3CASP7CASP6 | |
| SCHEMBL11657615 | 0.85 | SYK (0.59) | SYKCASP1CASP3CASP7CASP6 | |
| SCHEMBL20885259 | 0.85 | SYK (0.59) | SYKCASP1CASP3CASP7CASP6 | |
| SCHEMBL24050025 | 0.84 | SYK (0.56) | SYKCTSKCTSSCTSBELANE | |
| SCHEMBL5311477 | 0.83 | SYK (0.52) | SYKCASP1CASP3CASP7CASP6 | |
| SCHEMBL9608962 | 0.83 | SYK (0.58) | SYKCASP1CASP3CASP7CASP6 | |
| SCHEMBL12873000 | 0.83 | KLK5 (0.57) | SYKCTSLCTSKCTSSCTSB | |
| SCHEMBL12214464 | 0.83 | KLK5 (0.57) | SYKCTSLCTSKCTSSCTSB | |
| SCHEMBL6388701 | 0.83 | KLK5 (0.57) | SYKCTSLCTSKCTSSCTSB | |
| SCHEMBL25908075 | 0.82 | SYK (0.57) | SYKCASP3CTSLCTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015095227-A2 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2015-06-25 | — | — | WO | disclosed |