Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22698598 | 0.95 | HDAC8 (0.51) | HDAC8SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL18102693 | 0.93 | SSTR3 (0.51) | HDAC8SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL16847584 | 0.92 | HDAC8 (0.57) | HDAC8SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL15704359 | 0.89 | HDAC8 (0.46) | HDAC8SIRT2SIRT1SIRT3HDAC3 | |
| SCHEMBL15702069 | 0.87 | SSTR3 (0.51) | HDAC8SIRT2SIRT1SIRT3HDAC3 | |
| SCHEMBL15702064 | 0.86 | SSTR3 (0.52) | HDAC8SIRT2SIRT1SIRT3HDAC3 | |
| SCHEMBL25361946 | 0.84 | SSTR3 (0.50) | HDAC8SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL25361958 | 0.84 | SSTR3 (0.50) | HDAC8SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL22698633 | 0.84 | HDAC8 (0.44) | HDAC8SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL23286079 | 0.83 | HDAC8 (0.47) | HDAC8SIRT2SIRT1SIRT3SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015095227-A2 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2015-06-25 | — | — | WO | disclosed |