Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acarbose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY2A known ✓ | P04746 | 9/20 | 1.00 |
| ▸ | MGAM known ✓ | O43451 | 6/20 | 1.00 |
| ▸ | SI | P14410 | 5/20 | 1.00 |
| ▸ | GAA | P10253 | 4/20 | 1.00 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | TREH | O43280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acarbose SCHEMBL19736300 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL611277 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL681337 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL9929862 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL22252575 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL22252576 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| SCHEMBL14409049 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL4068725 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL14223718 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL22651301 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 51623 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4748438-A2 | ENTERICALLY DELIVERED BITTER OLIGOPEPTIDES FOR THE TREATMENT FOR TYPE 2 DIABETES | Cedars-Sinai Medical Center (US) | 2026-05-27 | — | — | EP | claimed |
| CN-121426937-B | Acarb virus nanobody Nb2 and application thereof | HARBIN VETERINARY Research Institute CAAS (HARBIN BRANCH OF CHINA ANIMAL HEALTH AND EPIDEMIOLOGY CENTER) (CN) | 2026-05-26 | — | — | CN | claimed |
| US-20260137751-A1 | ENTERICALLY DELIVERED BITTER OLIGOPEPTIDES FOR THE TREATMENT FOR TYPE 2 DIABETES | CEDARS-SINAI MEDICAL CENTER (US) | 2026-05-21 | — | — | US | claimed |
| US-12629340-B2 | Modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders | EMPROS PHARMA AB (SE) | 2026-05-19 | — | — | US | claimed |
| CN-122055374-A | Lipid compounds and compositions for tissue-specific delivery of active substances | 韩国生命工学研究院 | 2026-05-15 | — | — | CN | claimed |
| CN-122038522-A | Method for culturing bulk drug production strain based on morphology and physiological parameters | 丽珠集团新北江制药股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| US-12624116-B2 | Methods of treating severe insulin resistance by interfering with glucagon receptor signaling | REGENERON PHARMACEUTICALS, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-20260124282-A1 | DECORIN FOR ITS USE IN THE TREATMENT OF DIABETES | CENTRE EUROPEEN D'ETUDE DU DIABETE (FR) | 2026-05-07 | — | — | US | claimed |
| EP-4734978-A2 | COMBINATION THERAPIES USING PSILOCYBIN | University of Padova (IT) | 2026-05-06 | — | — | EP | claimed |
| WO-2026087680-A1 | TREATMENT FOR CARDIOVASCULAR DISEASE | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| EP-0226121-B1 | COMPOSITION CONTAINING VERY PURE ACARBOSE | BAYER AG (DE) | 1992-01-22 | — | — | EP | claimed |
| CN-1013866-B | PROCESS FOR PREPARATION OF HIGHLY PURE ACARBOSE | BAYER AG (DE) | 1991-09-11 | — | — | CN | claimed |
| EP-0418553-A1 | High potency, rapidly resorbable glibenclamide preparations, process for their preparation and their use | Bauer, Kurt H. Prof. Dr. (DE) | 1991-03-27 | — | — | EP | claimed |
| US-4904769-A | Highly pure acarbose | BAYER AKTIENGESELLSCHAFT (DE) | 1990-02-27 | — | — | US | claimed |
| EP-0185161-B1 | MACROPOROUS BEAD POLYMERS FOR THE PURIFICATION OF ACARBOSE | BAYER AG (DE) | 1988-11-23 | — | — | EP | claimed |
| US-4767850-A | CATIONIC EXCHANGER BY FREE RADICAL POLYMERIZATION OF VINYL MONOMERS, SULFONATED | BAYER AKTIENGESELLSCHAFT (DE) | 1988-08-30 | — | — | US | claimed |
| CN-86108259-A | Highly purified acarbose | — | 1987-07-29 | — | — | CN | claimed |
| EP-0226121-A2 | Composition containing very pure acarbose | BAYER AG (DE) | 1987-06-24 | — | — | EP | claimed |
| EP-0185161-A1 | Macroporous bead polymers for the purification of acarbose | BAYER AG (DE) | 1986-06-25 | — | — | EP | claimed |
| US-4575487-A | IN GLUCOAMYLASE PREPARATION | MILES LABORATORIES, INC. (US) | 1986-03-11 | — | — | US | claimed |