Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.77 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.77 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.77 |
| ▸ | PIM1 | P11309 | 1/20 | 0.77 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.77 |
| ▸ | FLT4 | P35916 | 1/20 | 0.77 |
| ▸ | FLT3 | P36888 | 1/20 | 0.77 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.77 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.77 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.77 |
| ▸ | GSK3A | P49840 | 1/20 | 0.77 |
| ▸ | GSK3B | P49841 | 1/20 | 0.77 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.77 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.77 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.77 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.77 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.77 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.77 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.77 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1684751 | 0.90 | CSNK2A1 (0.77) | CDK2PRKD3MAP4K4PIM1RPS6KB1 | |
| Bromide SCHEMBL18040664 | 0.89 | MAPT (0.77) | CDK2PRKD3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL1684637 | 0.87 | PRKD3 (1.00) | CDK2PRKD3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL1684622 | 0.87 | MAPT (0.98) | CDK2PRKD3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL3688533 | 0.87 | CSNK2A1 (0.76) | CDK2PRKD3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL4148720 | 0.87 | SYK (0.62) | CDK2PRKD3MAP4K4PIM1RPS6KB1 | |
| Bromide SCHEMBL18040695 | 0.86 | PRKD3 (0.98) | CDK2PRKD3MAP4K4PIM1RPS6KB1 | |
| Bromide SCHEMBL18040791 | 0.86 | MAPT (1.00) | CDK2PRKD3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL1684929 | 0.85 | MAPT (0.81) | CDK2PRKD3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL1684697 | 0.85 | MAPT (0.81) | CDK2PRKD3MAP4K4PIM1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306836-B1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2016-09-07 | — | — | EP | claimed |
| US-8680113-B2 | BMI-1 protein expression modulators | PTC THERAPEUTICS, INC. (US) | 2014-03-25 | — | — | US | claimed |
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2011-08-04 | — | — | US | claimed |
| EP-2306836-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC Therapeutics, Inc. (US) | 2011-04-13 | — | — | EP | claimed |
| WO-2010002985-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | claimed |
| US-20090209573-A1 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2009-08-20 | — | — | US | claimed |
| EP-1804803-A4 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2008-07-30 | — | — | EP | claimed |
| CN-101083996-A | Compounds and compositions as hedgehog pathway modulators | IRM LLC (BM) | 2007-12-05 | — | — | CN | claimed |
| EP-1804803-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM, LLC (BM) | 2007-07-11 | — | — | EP | claimed |
| WO-2006050351-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2006-05-11 | — | — | WO | claimed |
| EP-3111956-B1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2019-05-08 | — | — | EP | disclosed |
| EP-3111956-A1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC Therapeutics, Inc. (US) | 2017-01-04 | — | — | EP | disclosed |
| EP-2306836-B1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2016-09-07 | — | — | EP | disclosed |
| US-8680113-B2 | BMI-1 protein expression modulators | PTC THERAPEUTICS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2011-08-04 | — | — | US | disclosed |
| US-20090209573-A1 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2009-08-20 | — | — | US | disclosed |
| EP-1804803-A4 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2008-07-30 | — | — | EP | disclosed |
| CN-101083996-A | Compounds and compositions as hedgehog pathway modulators | IRM LLC (BM) | 2007-12-05 | — | — | CN | disclosed |
| EP-1804803-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM, LLC (BM) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006050351-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | BMI1, CREBBP, BAZ2A | CDK2 1442/4885PRKD3 1504/4885MAP4K4 3451/4885 |
| US-20090209573-A1 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | GLI1, SHH, SMO | CDK2 1149/4885PRKD3 1077/4885MAP4K4 2820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.