Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1282918 | 0.87 | ABL1 (0.34) | — | |
| SCHEMBL1685280 | 0.81 | RET (0.32) | PIK3CDPIK3CBPIK3CGPIK3R1PIK3CA | |
| SCHEMBL1282131 | 0.79 | DGAT1 (0.30) | GSK3BDYRK1A | |
| SCHEMBL1283805 | 0.78 | — | — | |
| SCHEMBL1282134 | 0.78 | ABL1 (0.35) | — | |
| SCHEMBL1282298 | 0.77 | ABL1 (0.37) | — | |
| SCHEMBL1282576 | 0.74 | ABL1 (0.37) | — | |
| SCHEMBL1282496 | 0.73 | ABL1 (0.40) | — | |
| SCHEMBL1282255 | 0.73 | ABL1 (0.37) | PIK3CG | |
| SCHEMBL1282961 | 0.73 | AOC3 (0.31) | PIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012045124-A1 | BACTERIA TOPOISOMERASE II INHIBITING 2-ETHYLCARBAMOYLAMINO-1, 3-BENZOTHIAZOL-5-YLS | BIOTA EUROPE LTD (GB) | 2012-04-12 | — | — | WO | disclosed |