Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20078274 | 0.88 | BRD4 (0.46) | AHRAOC3BRD4RAB9ANPC1 | |
| SCHEMBL399327 | 0.87 | AHR (0.50) | AHRAOC3BRD4RAB9ANPC1 | |
| SCHEMBL30435112 | 0.87 | AHR (0.50) | AHRAOC3BRD4RAB9ANPC1 | |
| SCHEMBL5692312 | 0.83 | AHR (0.56) | AHRAOC3BRD4RAB9ANPC1 | |
| SCHEMBL26462532 | 0.83 | AHR (0.47) | AHRAOC3BRD4RAB9ANPC1 | |
| SCHEMBL20078280 | 0.82 | BRD4 (0.41) | AHRAOC3BRD4RAB9ANPC1 | |
| SCHEMBL28864005 | 0.82 | AHR (0.53) | AHRAOC3BRD4RAB9ANPC1 | |
| SCHEMBL7379568 | 0.80 | AHR (0.45) | AHRAOC3BRD4RAB9ANPC1 | |
| SCHEMBL12045263 | 0.80 | KDM4E (0.46) | AHRAOC3BRD4RAB9ANPC1 | |
| SCHEMBL7022968 | 0.80 | AHR (0.51) | AHRAOC3BRD4RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328513-A2 | DIINDOLYLMETHANE AND C-SUBSTITUTED DIINDOLYLMETHANE COMPOSITIONS AND METHODS FOR THE TREATMENT OF MULTIPLE CANCERS | The Texas A & M University System (US) | 2003-07-23 | — | — | EP | claimed |
| WO-2002028832-A2 | DIINDOLYLMETHANE AND C-SUBSTITUTED DIINDOLYLMETHANE COMPOSITIONS AND METHODS FOR THE TREATMENT OF MULTIPLE CANCERS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 2002-04-11 | — | — | WO | claimed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | claimed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | claimed |
| EP-2314294-A2 | 3,3'-diindolylmethane immune activating compositions | The Regents of The University of California (US) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010042657-A1 | USE OF DIINDOLYLMETHANE (DIM) COMPOUNDS AND DERIVATIVES AS NEUROPROTECTIVE AGENTS | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-04-15 | — | — | WO | disclosed |
| EP-1811842-A4 | 3,3'-DIINDOLYLMETHANE IMMUNE ACTIVATING COMPOSITIONS | UNIV CALIFORNIA (US) | 2008-02-27 | — | — | EP | disclosed |
| EP-1811842-A2 | 3,3'-DIINDOLYLMETHANE IMMUNE ACTIVATING COMPOSITIONS | The Regents of the University of California (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006110299-A1 | 3,3'-DIINDOLYLMETHANE COMPOSITIONS INHIBIT ANGIOGENESIS | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-10-19 | — | — | WO | disclosed |
| US-20060229355-A1 | 3.3'-Diindolylmethane compositions inhibit angiogenesis | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2006-10-12 | — | — | US | disclosed |
| WO-2006068713-A2 | 3,3'-DIINDOLYLMETHANE IMMUNE ACTIVATING COMPOSITIONS | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-06-29 | — | — | WO | disclosed |
| EP-1328513-A2 | DIINDOLYLMETHANE AND C-SUBSTITUTED DIINDOLYLMETHANE COMPOSITIONS AND METHODS FOR THE TREATMENT OF MULTIPLE CANCERS | The Texas A & M University System (US) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002028832-A2 | DIINDOLYLMETHANE AND C-SUBSTITUTED DIINDOLYLMETHANE COMPOSITIONS AND METHODS FOR THE TREATMENT OF MULTIPLE CANCERS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 2002-04-11 | — | — | WO | disclosed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229355-A1 | 3.3'-Diindolylmethane compositions inhibit angiogenesis | FLT4, FLT1, PGF | AHR 772/4885AOC3 1090/4885BRD4 1854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.